Tbio OPCML Opioid-binding protein/cell adhesion molecule

Protein Summary

Description

Binds opioids in the presence of acidic lipids; probably involved in cell contact. This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• Q14982
• B2CZX2
• B7ZLQ1
• Q17RN7
• Q7Z3W6
• OBCAM

Gene Name

• OPCML

Ensembl ID

• ENST00000331898
• ENSP00000330862
• ENSG00000183715
• ENST00000374778
• ENSP00000363910
• ENST00000524381
• ENSP00000434750
• ENST00000541867
• ENSP00000445496
• ENST00000612177
• ENSP00000482061

Symbol

• IGLON1
• OBCAM
• OPCM
• OBCAM
• IGLON1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
disease	0.74
microRNA	0.74
protein domain	0.73
phenotype	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.89   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 197   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.89   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0