You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NUMA1
Nuclear mitotic apparatus protein 1

Protein Summary
Description
Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:7769006, PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:12445386, PubMed:11956313). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351960
  • ENSP00000260051
  • ENSG00000137497
  • ENST00000358965
  • ENSP00000351851
  • ENST00000393695
  • ENSP00000377298
  • ENST00000613205
  • ENSP00000480172
  • ENST00000620566
  • ENSP00000478624

Symbol
  • NMP22
  • NUMA
  • NUMA
  • NMP-22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
disease perturbation
0.9
drug perturbation
0.87
cellular component
0.85
ligand (protein) perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 651.55   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 375   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 651.55   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 375   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary albumin to creatinine ratio
3
1
3
38.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary albumin to creatinine ratio
3
38.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear mitotic apparatus protein 1
VGNC:1076
451398
Macaque
nuclear mitotic apparatus protein 1
718231
Mouse
MGI:2443665
101706
Rat
RGD:1308777
308870
Dog
nuclear mitotic apparatus protein 1
VGNC:44042
485213
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear mitotic apparatus protein 1
Macaque
nuclear mitotic apparatus protein 1
Mouse
Rat
Dog
nuclear mitotic apparatus protein 1
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
M Phase
Reactome
Mitotic Prometaphase
Reactome
Mitotic Prophase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
M Phase
Mitotic Prometaphase
Mitotic Prophase
Gene Ontology Terms (61)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Protein-Protein Interactions (183)
1 – 10 of 183
EPB41L3
Tbio
Novelty: 0.00915217
p_int: 0.999170408
p_ni: 0.000829593
Score: 0.339
Data Source: BioPlex,STRINGDB
WDR83
Tbio
Novelty: 0.11602568
p_int: 0.998883506
p_ni: 0.001116494
Score: 0.546
Data Source: BioPlex,STRINGDB
SCOC
Tbio
Novelty: 0.05277646
p_int: 0.997471886
p_ni: 0.002528114
Score: 0.189
Data Source: BioPlex,STRINGDB
GPSM1
Tbio
Novelty: 0.03510582
p_int: 0.996937927
p_ni: 0.003062073
Score: 0.921
Data Source: BioPlex,STRINGDB
TCP10L
Tbio
Novelty: 0.24089479
p_int: 0.996341121
p_ni: 0.003658879
Score: 0.173
Data Source: BioPlex,STRINGDB
HAUS6
Tbio
Novelty: 0.11011519
Score: 0.99
Data Source: STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.981
Data Source: STRINGDB
TUBG1
Tbio
Novelty: 0.02252882
Score: 0.975
Data Source: STRINGDB
PCNT
Tbio
Novelty: 0.00369505
Score: 0.968
Data Source: STRINGDB
CENPJ
Tbio
Novelty: 0.01337231
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score  651.55

PubMed score by year
PubTator Score  464.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer