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Tbio
KPNB1
Importin subunit beta-1

Protein Summary
Description
Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal prote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290158
  • ENSP00000290158
  • ENSG00000108424
  • ENST00000535458
  • ENSP00000438253
  • ENST00000540627
  • ENSP00000438964

Symbol
  • NTF97
  • IMB1
  • IPO1
  • IPOB
  • Impnb
  • NTF97
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
transcription factor perturbation
0.99
viral protein
0.98


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.64   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.64   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
5
6
96.9
apolipoprotein B measurement
2
3
3
92.8
mean platelet volume
1
2
2
90.8
total cholesterol measurement
3
4
5
90.2
mathematical ability
3
2
3
86.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
6
96.9
apolipoprotein B measurement
3
92.8
mean platelet volume
2
90.8
total cholesterol measurement
5
90.2
mathematical ability
3
86.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
karyopherin subunit beta 1
VGNC:9436
455176
Macaque
karyopherin subunit beta 1
694121
Mouse
MGI:107532
16211
Rat
RGD:2909
24917
Dog
karyopherin subunit beta 1
VGNC:42506
491042
Species
Name
OMA
EggNOG
Inparanoid
Chimp
karyopherin subunit beta 1
Macaque
karyopherin subunit beta 1
Mouse
Rat
Dog
karyopherin subunit beta 1
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14974-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Apoptosis
Reactome
Apoptosis induced DNA fragmentation
Reactome
Apoptotic execution phase
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Apoptosis
Apoptosis induced DNA fragmentation
Apoptotic execution phase
Cytokine Signaling in Immune system
Gene Ontology Terms (39)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (404)
1 – 10 of 404
RAN
Tchem
Family:  Enzyme
Novelty:  0.00160888
p_int:  0.990567781
p_ni:  0.009432219
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
TSR1
Tbio
Novelty:  0.01639069
p_int:  0.973679694
p_ni:  0.026320306
Score:  0.308
Data Source:  BioPlex,STRINGDB
KPNA2
Tbio
Novelty:  0.00506958
p_int:  0.952895149
p_ni:  0.047104851
Score:  0.999
Data Source:  BioPlex,STRINGDB
NUP50
Tbio
Novelty:  0.03424725
p_int:  0.927715628
p_ni:  0.072284372
Score:  0.958
Data Source:  BioPlex,STRINGDB
B2M
Tbio
Novelty:  0.00011248
p_int:  0.922661777
p_ni:  0.077338223
Score:  0.914
Data Source:  BioPlex,STRINGDB
SIX2
Tbio
Family:  TF
Novelty:  0.01046481
p_int:  0.866059939
p_ni:  0.133940061
Score:  0.175
Data Source:  BioPlex,STRINGDB
HP1BP3
Tbio
Novelty:  0.07014109
p_int:  0.824004118
p_ni:  0.175995882
Score:  0.188
Data Source:  BioPlex,STRINGDB
MOGS
Tbio
Family:  Enzyme
Novelty:  0.00527993
p_int:  0.790288915
p_ni:  0.209711085
Data Source:  BioPlex
RCC1
Tbio
Novelty:  0.00260884
p_int:  0.776046398
p_ni:  0.223953602
Score:  0.989
Data Source:  BioPlex,STRINGDB
H2BFWT
Tbio
Novelty:  0.16138632
p_int:  0.754669901
p_ni:  0.245330099
Data Source:  BioPlex
Publication Statistics
PubMed Score  67.64

PubMed score by year
PubTator Score  35.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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