SLC10A1
Sodium/bile acid cotransporter
Protein Summary
The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. (Microbial infection) Acts as a receptor for hepatitis B virus. The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]
- ENST00000216540
- ENSP00000216540
- ENSG00000100652
- NTCP
- NTCP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.88 | ||
cell type or tissue | 0.84 | ||
drug | 0.75 | ||
disease | 0.67 | ||
kinase perturbation | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 783.38 (req: < 5)
Gene RIFs: 48 (req: <= 3)
Antibodies: 200 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 783.38 (req: >= 5)
Gene RIFs: 48 (req: > 3)
Antibodies: 200 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 8
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (8)
Protein-Protein Interactions (99)
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (12)
Reactome (5)
KEGG (2)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Bile acid and bile salt metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of steroids | ||||
Reactome | Recycling of bile acids and salts | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Bile acid and bile salt metabolism | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of steroids | ||||
Recycling of bile acids and salts | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (2)
Components (3)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 4 | 2 | 4 | 89.2 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 80.6 | |||||
digit length ratio | 3 | 1 | 4 | 75.4 | |||||
appendicular lean mass | 1 | 2 | 2 | 71.4 | |||||
balding measurement | 1 | 1 | 1 | 64.9 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 4 | 89.2 | |||||
mean corpuscular hemoglobin concentration | 1 | 80.6 | |||||
digit length ratio | 4 | 75.4 | |||||
appendicular lean mass | 2 | 71.4 | |||||
balding measurement | 1 | 64.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | solute carrier family 10 member 1 | VGNC:8206 | 453001 | |||||
Macaque | solute carrier family 10 member 1 | 712925 | ||||||
Mouse | MGI:97379 | 20493 | ||||||
Rat | RGD:3681 | 24777 | ||||||
Dog | solute carrier family 10 member 1 | VGNC:46211 | 480372 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | solute carrier family 10 member 1 | |||||
Macaque | solute carrier family 10 member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 10 member 1 | |||||
Publication Statistics
PubMed Score 783.38
PubMed score by year
PubTator Score 334.26
PubTator score by year
Related Publications
Text Mined References (58)
GeneRif Annotations (48)
Items per page:
0 of 0
PMID | Year | Title |
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