SLC10A1
Sodium/bile acid cotransporter
Protein Classes
Protein Summary
The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. (Microbial infection) Acts as a receptor for hepatitis B virus. The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]
- ENST00000216540
- ENSP00000216540
- ENSG00000100652
- NTCP
- NTCP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.88 | ||
cell type or tissue | 0.84 | ||
drug | 0.75 | ||
disease | 0.67 | ||
kinase perturbation | 0.6 | ||
Related Tools
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 744.31 (req: < 5)
Gene RIFs: 48 (req: <= 3)
Antibodies: 200 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 744.31 (req: >= 5)
Gene RIFs: 48 (req: > 3)
Antibodies: 200 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 8
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
Active Ligands (8)
1 – 8 of 8
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | solute carrier family 10 member 1 | VGNC:8206 | 453001 | |||||
Macaque | solute carrier family 10 member 1 | 712925 | ||||||
Mouse | MGI:97379 | 20493 | ||||||
Rat | RGD:3681 | 24777 | ||||||
Dog | solute carrier family 10 member 1 | VGNC:46211 | 480372 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | solute carrier family 10 member 1 | |||||
Macaque | solute carrier family 10 member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 10 member 1 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (12)
Reactome (5)
KEGG (2)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Bile acid and bile salt metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of steroids | ||||
Reactome | Recycling of bile acids and salts | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Bile acid and bile salt metabolism | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of steroids | ||||
Recycling of bile acids and salts | ||||
Gene Ontology Terms (6)
Functions (2)
Components (3)
Processes (1)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (99)
1 – 10 of 99
ALB
Novelty: 0.00000616
Score: 0.939
Data Source: Reactome,STRINGDB
ABCB11
Family: Transporter
Novelty: 0.00097529
Score: 0.912
Data Source: STRINGDB
SLCO1B1
Family: Transporter
Novelty: 0.00126613
Score: 0.867
Data Source: STRINGDB
SLCO1B3
Family: Transporter
Novelty: 0.0031518
Score: 0.857
Data Source: STRINGDB
CYP7A1
Family: Enzyme
Novelty: 0.00148194
Score: 0.838
Data Source: STRINGDB
SLCO1A2
Family: Transporter
Novelty: 0.00248357
Score: 0.836
Data Source: STRINGDB
NR0B2
Family: NR
Novelty: 0.0009861
Score: 0.835
Data Source: STRINGDB
SLC10A7
Family: Transporter
Novelty: 0.15556211
Score: 0.809
Data Source: STRINGDB
NR1H4
Family: NR
Novelty: 0.00067092
Score: 0.802
Data Source: STRINGDB
CYP8B1
Family: Enzyme
Novelty: 0.01243408
Score: 0.781
Data Source: STRINGDB
Publication Statistics
PubMed Score 744.31
PubMed score by year
PubTator Score 334.26
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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