Tclin SLC10A1 Sodium/bile acid cotransporter

Protein Summary

Description

The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. (Microbial infection) Acts as a receptor for hepatitis B virus. The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q14973
• B9EGB6
• Q2TU29

Gene Name

• SLC10A1

Ensembl ID

• ENST00000216540
• ENSP00000216540
• ENSG00000100652

Symbol

• NTCP
• NTCP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
cell type or tissue	0.84
drug	0.75
disease	0.67
kinase perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Sodium/bile Acid Cotransporter

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc10 Family Of Sodium-bile Acid Co-transporters / Sodium/bile Acid Cotransporter

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 954.82   (req: < 5)

Gene RIFs: 90   (req: <= 3)

Antibodies: 200   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 954.82   (req: >= 5)

Gene RIFs: 90   (req: > 3)

Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2