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Tchem
SLC10A1
Sodium/bile acid cotransporter

Protein Summary
Description
The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. (Microbial infection) Acts as a receptor for hepatitis B virus. The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216540
  • ENSP00000216540
  • ENSG00000100652

Symbol
  • NTCP
  • NTCP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
cell type or tissue
0.84
drug
0.75
disease
0.67
kinase perturbation
0.6


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 744.31   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 744.31   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 10 member 1
VGNC:8206
453001
Macaque
solute carrier family 10 member 1
712925
Mouse
MGI:97379
20493
Rat
RGD:3681
24777
Dog
solute carrier family 10 member 1
VGNC:46211
480372
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 10 member 1
Macaque
solute carrier family 10 member 1
Mouse
Rat
Dog
solute carrier family 10 member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14973-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Recycling of bile acids and salts
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Metabolism
Metabolism of lipids
Metabolism of steroids
Recycling of bile acids and salts
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (99)
1 – 10 of 99
ALB
Tchem
Novelty: 0.00000616
Score: 0.939
Data Source: Reactome,STRINGDB
ABCB11
Tchem
Family: Transporter
Novelty: 0.00097529
Score: 0.912
Data Source: STRINGDB
SLCO1B1
Tchem
Family: Transporter
Novelty: 0.00126613
Score: 0.867
Data Source: STRINGDB
SLCO1B3
Tchem
Family: Transporter
Novelty: 0.0031518
Score: 0.857
Data Source: STRINGDB
CYP7A1
Tbio
Family: Enzyme
Novelty: 0.00148194
Score: 0.838
Data Source: STRINGDB
SLCO1A2
Tchem
Family: Transporter
Novelty: 0.00248357
Score: 0.836
Data Source: STRINGDB
NR0B2
Tchem
Family: NR
Novelty: 0.0009861
Score: 0.835
Data Source: STRINGDB
SLC10A7
Tbio
Family: Transporter
Novelty: 0.15556211
Score: 0.809
Data Source: STRINGDB
NR1H4
Tclin
Family: NR
Novelty: 0.00067092
Score: 0.802
Data Source: STRINGDB
CYP8B1
Tbio
Family: Enzyme
Novelty: 0.01243408
Score: 0.781
Data Source: STRINGDB
Publication Statistics
PubMed Score  744.31

PubMed score by year
PubTator Score  334.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer