Pharos : Target Details

Tclin

Protein Summary

Description

The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. (Microbial infection) Acts as a receptor for hepatitis B virus. The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

Gene Name

SLC10A1

Ensembl ID

ENST00000216540
ENSP00000216540
ENSG00000100652

Symbol

NTCP
NTCP

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88

cell type or tissue	0.84

drug	0.75

disease	0.67

kinase perturbation	0.6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 783.38 (req: < 5)

View Publications

Gene RIFs: 48 (req: <= 3)

View Gene RIFs

Antibodies: 200 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 783.38 (req: >= 5)

Gene RIFs: 48 (req: > 3)

Antibodies: 200 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Explore Active Ligands

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2

Explore Approved Drugs

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools

RESOLUTE

RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Approved Drugs (2)

1 – 2 of 2

irbesartan

bulevirtide

Active Ligands (8)

1 – 8 of 8

Protein-Protein Interactions (99)

1 – 10 of 99

See Interactions on String-DB

ALB

Tchem

Novelty: 0.00000616

Score: 0.939

Data Source: Reactome,STRINGDB

ABCB11

Tchem

Family: Transporter

Novelty: 0.00097529

Score: 0.912

Data Source: STRINGDB

SLCO1B1

Tchem

Family: Transporter

Novelty: 0.00126613

Score: 0.867

Data Source: STRINGDB

SLCO1B3

Tchem

Family: Transporter

Novelty: 0.0031518

Score: 0.857

Data Source: STRINGDB

CYP7A1

Tchem

Family: Enzyme

Novelty: 0.00148194

Score: 0.838

Data Source: STRINGDB

SLCO1A2

Tchem

Family: Transporter

Novelty: 0.00248357

Score: 0.836

Data Source: STRINGDB

NR0B2

Tchem

Family: NR

Novelty: 0.0009861

Score: 0.835

Data Source: STRINGDB

SLC10A7

Tbio

Family: Transporter

Novelty: 0.15556211

Score: 0.809

Data Source: STRINGDB

NR1H4

Tclin

Family: NR

Novelty: 0.00067092

Score: 0.802

Data Source: STRINGDB

CYP8B1

Tchem

Family: Enzyme

Novelty: 0.01243408

Score: 0.781

Data Source: STRINGDB

Pathways (12)

Reactome (5)

KEGG (2)

WikiPathways (5)

Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Bile acid and bile salt metabolism	43 targets	R-HSA-194068

Reactome	Metabolism	2112 targets	R-HSA-1430728

Reactome	Metabolism of lipids	740 targets	R-HSA-556833

Reactome	Metabolism of steroids	151 targets	R-HSA-8957322

Reactome	Recycling of bile acids and salts	16 targets	R-HSA-159418

Name	Explore in Pharos	Explore in Source
Bile acid and bile salt metabolism	43 targets	R-HSA-194068

Metabolism	2112 targets	R-HSA-1430728

Metabolism of lipids	740 targets	R-HSA-556833

Metabolism of steroids	151 targets	R-HSA-8957322

Recycling of bile acids and salts	16 targets	R-HSA-159418

Gene Ontology Terms (6)

Functions (2)

Components (3)

Processes (1)

Items per page:

1 – 2 of 2

GO Term	Evidence	Assigned by
bile acid:sodium symporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

virus receptor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

GWAS Traits (9)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
red blood cell distribution width	EFO_0005192	4	2	4	89.2

mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1	80.6

digit length ratio	EFO_0004841	3	1	4	75.4

appendicular lean mass	EFO_0004980	1	2	2	71.4

balding measurement	EFO_0007825	1	1	1	64.9

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
red blood cell distribution width	EFO_0005192	4	89.2

mean corpuscular hemoglobin concentration	EFO_0004528	1	80.6

digit length ratio	EFO_0004841	4	75.4

appendicular lean mass	EFO_0004980	2	71.4

balding measurement	EFO_0007825	1	64.9

Beta Count

Odds Ratio

Find similar targets by:

UniProt Keyword

No Header	No Header
Complete proteome

Glycoprotein

Host cell receptor for virus entry

Host-virus interaction

Ion transport

Membrane

Polymorphism

Receptor

Reference proteome

Sodium

GWAS Trait

No Header	No Header
appendicular lean mass

balding measurement

digit length ratio

heel bone mineral density

mean corpuscular hemoglobin concentration

mean corpuscular volume

platelet crit

red blood cell distribution width

triglyceride measurement

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID
Chimp	solute carrier family 10 member 1	VGNC:8206	453001

Macaque	solute carrier family 10 member 1		712925

Mouse	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	MGI:97379	20493

Rat	solute carrier family 10 member 1	RGD:3681	24777

Dog	solute carrier family 10 member 1	VGNC:46211	480372

Species	Name	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 10 member 1

Macaque	solute carrier family 10 member 1

Mouse	solute carrier family 10 (sodium/bile acid cotransporter family), member 1

Rat	solute carrier family 10 member 1

Dog	solute carrier family 10 member 1

Publication Statistics

PubMed Score 783.38

PubMed score by year

PubTator Score 334.26

PubTator score by year