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Tbio
RAB39A
Ras-related protein Rab-39A

Protein Summary
Description
Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes. Negatively regulates LPS-induced autophagosome formation in macrophages possibly by implicating PI3K (PubMed:24349490). May be involved in multiple neurite formation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320578
  • ENSP00000322594
  • ENSG00000179331

Symbol
  • RAB39
  • RAB39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
histone modification site profile
0.76
cellular component
0.75
transcription factor
0.71
interacting protein
0.7


Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.77   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.77   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RAB39A, member RAS oncogene family
707451
Mouse
MGI:2442855
270160
Rat
RGD:1311286
315668
Horse
RAB39A, member RAS oncogene family
VGNC:22115
100061694
Opossum
RAB39A, member RAS oncogene family
100026870
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RAB39A, member RAS oncogene family
Mouse
Rat
Horse
RAB39A, member RAS oncogene family
Opossum
RAB39A, member RAS oncogene family
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14964-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (98)
1 – 10 of 98
RAB33B
Tbio
Family:  Enzyme
Novelty:  0.06381712
Score:  0.933
Data Source:  STRINGDB
RAB36
Tbio
Family:  Enzyme
Novelty:  0.14109545
Score:  0.93
Data Source:  STRINGDB
RAB34
Tbio
Family:  Enzyme
Novelty:  0.03645677
Score:  0.93
Data Source:  STRINGDB
RAB34
Tbio
Novelty:  0.03645677
Score:  0.93
Data Source:  STRINGDB
RAB33A
Tbio
Family:  Enzyme
Novelty:  0.11617001
Score:  0.928
Data Source:  STRINGDB
RAB6B
Tbio
Family:  Enzyme
Novelty:  0.0865097
Score:  0.927
Data Source:  STRINGDB
RAB6A
Tchem
Family:  Enzyme
Novelty:  0.00546034
Score:  0.927
Data Source:  STRINGDB
RAB43
Tbio
Family:  Enzyme
Novelty:  0.07527576
Score:  0.927
Data Source:  STRINGDB
RAB41
Tdark
Family:  Enzyme
Score:  0.926
Data Source:  STRINGDB
RAB12
Tbio
Family:  Enzyme
Novelty:  0.05361391
Score:  0.926
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.77

PubMed score by year
PubTator Score  12.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer