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Tclin
GRIN2C
Glutamate receptor ionotropic, NMDA 2C

Protein Summary
Description
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293190
  • ENSP00000293190
  • ENSG00000161509

Symbol
  • NMDAR2C
  • NR2C
  • GluN2C
  • NMDAR2C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
ligand (chemical)
0.92
protein domain
0.85
gene perturbation
0.8
drug
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.67   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.67   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor NMDA type subunit 2C
VGNC:12238
454868
Macaque
glutamate ionotropic receptor NMDA type subunit 2C
699216
Mouse
MGI:95822
14813
Rat
RGD:2739
24411
Dog
glutamate ionotropic receptor NMDA type subunit 2C
VGNC:41494
483302
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor NMDA type subunit 2C
Macaque
glutamate ionotropic receptor NMDA type subunit 2C
Mouse
Rat
Dog
glutamate ionotropic receptor NMDA type subunit 2C
Pathways (38)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
Long-term potentiation
Reactome
Negative regulation of NMDA receptor-mediated neuronal transmission
Reactome
Neurexins and neuroligins
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
Long-term potentiation
Negative regulation of NMDA receptor-mediated neuronal transmission
Neurexins and neuroligins
Protein-Protein Interactions (133)
1 – 10 of 133
DLG4
Tchem
Novelty: 0.00057285
Score: 0.98
Data Source: Reactome,STRINGDB
DLG3
Tbio
Novelty: 0.01196565
Score: 0.973
Data Source: Reactome,STRINGDB
GRIN1
Tclin
Family: IC
Novelty: 0.0011807
Score: 0.972
Data Source: Reactome,STRINGDB
DLG2
Tbio
Novelty: 0.00999909
Score: 0.959
Data Source: Reactome,STRINGDB
CAMK2A
Tchem
Family: Kinase
Novelty: 0.00534906
Score: 0.951
Data Source: STRINGDB
GRIA1
Tclin
Family: IC
Novelty: 0.0005008
Score: 0.95
Data Source: STRINGDB
GRIA2
Tclin
Family: IC
Novelty: 0.00141257
Score: 0.941
Data Source: STRINGDB
GRIA4
Tclin
Family: IC
Novelty: 0.00284417
Score: 0.939
Data Source: STRINGDB
GRIN2A
Tclin
Family: IC
Novelty: 0.00060035
Score: 0.936
Data Source: Reactome,STRINGDB
AKAP9
Tbio
Family: Enzyme
Novelty: 0.0106532
Score: 0.936
Data Source: STRINGDB
Publication Statistics
PubMed Score  209.67

PubMed score by year
PubTator Score  66.05

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer