You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
GRIN2C
Glutamate receptor ionotropic, NMDA 2C

Protein Summary
Description
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293190
  • ENSP00000293190
  • ENSG00000161509

Symbol
  • NMDAR2C
  • NR2C
  • GluN2C
  • NMDAR2C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
ligand (chemical)
0.92
protein domain
0.85
gene perturbation
0.8
drug
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.97   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.97   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Pathways (38)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
Long-term potentiation
Reactome
Negative regulation of NMDA receptor-mediated neuronal transmission
Reactome
Neurexins and neuroligins
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
Long-term potentiation
Negative regulation of NMDA receptor-mediated neuronal transmission
Neurexins and neuroligins
Protein-Protein Interactions (133)
1 – 10 of 133
DLG4
Tchem
Novelty: 0.00079421
Score: 0.98
Data Source: Reactome,STRINGDB
DLG3
Tbio
Novelty: 0.00904059
Score: 0.973
Data Source: Reactome,STRINGDB
GRIN1
Tclin
Family: IC
Novelty: 0.00132693
Score: 0.972
Data Source: Reactome,STRINGDB
DLG2
Tbio
Novelty: 0.01593948
Score: 0.959
Data Source: Reactome,STRINGDB
CAMK2A
Tchem
Family: Kinase
Novelty: 0.01196206
Score: 0.951
Data Source: STRINGDB
GRIA1
Tclin
Family: IC
Novelty: 0.00063312
Score: 0.95
Data Source: STRINGDB
GRIA2
Tclin
Family: IC
Novelty: 0.00187801
Score: 0.941
Data Source: STRINGDB
GRIA4
Tclin
Family: IC
Novelty: 0.00363124
Score: 0.939
Data Source: STRINGDB
GRIN2A
Tclin
Family: IC
Novelty: 0.00075253
Score: 0.936
Data Source: Reactome,STRINGDB
AKAP9
Tbio
Family: Enzyme
Novelty: 0.0055702
Score: 0.936
Data Source: STRINGDB
Publication Statistics
PubMed Score  158.97

PubMed score by year
PubTator Score  66.05

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer