You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GPNMB
Transmembrane glycoprotein NMB

Protein Summary
Description
Could be a melanogenic enzyme. The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258733
  • ENSP00000258733
  • ENSG00000136235
  • ENST00000381990
  • ENSP00000371420

Symbol
  • HGFIN
  • NMB
  • NMB
  • HGFIN
  • PLCA3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
transcription factor perturbation
0.88
small molecule perturbation
0.85
virus perturbation
0.72
cellular component
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.02   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 376   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.02   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 376   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
IL31RA
Tbio
Novelty:  0.00737445
p_int:  0.863767311
p_ni:  0.135952578
p_wrong:  0.000280112
Score:  0.187
Data Source:  BioPlex,STRINGDB
TFEB
Tbio
Family:  TF
Novelty:  0.00248413
p_int:  0.827229687
p_ni:  0.171973156
p_wrong:  0.000797156
Score:  0.434
Data Source:  BioPlex,STRINGDB
FBXL4
Tbio
Novelty:  0.04286856
p_int:  0.754173915
p_ni:  0.245825916
p_wrong:  1.69e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.966
Data Source:  Reactome,STRINGDB
PTK6
Tchem
Family:  Kinase
Novelty:  0.00480214
Score:  0.944
Data Source:  Reactome,STRINGDB
LRRK2
Tchem
Family:  Kinase
Novelty:  0.00068078
Score:  0.936
Data Source:  Reactome,STRINGDB
HBEGF
Tbio
Novelty:  0.00105355
Score:  0.915
Data Source:  Reactome,STRINGDB
HIF1A
Tchem
Family:  TF
Novelty:  0.00011503
Score:  0.909
Data Source:  STRINGDB
TMSB10
Tbio
Novelty:  0.00779761
Score:  0.845
Data Source:  STRINGDB
ANXA5
Tbio
Novelty:  0.00007584
Score:  0.745
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
PTK6 promotes HIF1A stabilization (R-HSA-8857538)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
PTK6 promotes HIF1A stabilization
Reactome
Signal Transduction
Reactome
Signaling by Non-Receptor Tyrosine Kinases
Reactome
Signaling by PTK6
Name
Explore in Pharos
Explore in Source
PTK6 promotes HIF1A stabilization
Signal Transduction
Signaling by Non-Receptor Tyrosine Kinases
Signaling by PTK6
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Mutant Phenotype (IMP)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
ParkinsonsUK-UCL
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
1
1.1
81.6
C-reactive protein measurement
1
2
2
66.6
1
1
0
3.9
36.9
electrocardiography
1
1
2
4.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
81.6
C-reactive protein measurement
2
66.6
0
3.9
36.9
electrocardiography
2
4.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycoprotein nmb
VGNC:7386
463289
Macaque
glycoprotein nmb
704990
Mouse
MGI:1934765
93695
Rat
RGD:71008
113955
Dog
glycoprotein nmb
VGNC:41389
482355
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycoprotein nmb
Macaque
glycoprotein nmb
Mouse
Rat
Dog
glycoprotein nmb
Publication Statistics
PubMed Score 225.02
PubMed score by year
PubTator Score 92.94
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title