GPNMB
Transmembrane glycoprotein NMB
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.96 | ||
transcription factor perturbation | 0.88 | ||
small molecule perturbation | 0.85 | ||
virus perturbation | 0.72 | ||
cellular component | 0.6 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | PTK6 promotes HIF1A stabilization | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Non-Receptor Tyrosine Kinases | ||||
Reactome | Signaling by PTK6 | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
PTK6 promotes HIF1A stabilization | ||||
Signal Transduction | ||||
Signaling by Non-Receptor Tyrosine Kinases | ||||
Signaling by PTK6 | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Mutant Phenotype (IMP) | ParkinsonsUK-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | ParkinsonsUK-UCL | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
3 | 2 | 1 | 1.1 | 81.6 | |||||
C-reactive protein measurement | 1 | 2 | 2 | 66.6 | |||||
1 | 1 | 0 | 3.9 | 36.9 | |||||
electrocardiography | 1 | 1 | 2 | 4.2 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
1 | 1.1 | 81.6 | |||||
C-reactive protein measurement | 2 | 66.6 | |||||
0 | 3.9 | 36.9 | |||||
electrocardiography | 2 | 4.2 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | glycoprotein nmb | VGNC:7386 | 463289 | |||||
Macaque | glycoprotein nmb | 704990 | ||||||
Mouse | MGI:1934765 | 93695 | ||||||
Rat | RGD:71008 | 113955 | ||||||
Dog | glycoprotein nmb | VGNC:41389 | 482355 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | glycoprotein nmb | |||||
Macaque | glycoprotein nmb | |||||
Mouse | ||||||
Rat | ||||||
Dog | glycoprotein nmb | |||||
PMID | Year | Title |
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