GPNMB
Transmembrane glycoprotein NMB
Protein Summary
Could be a melanogenic enzyme. The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000258733
- ENSP00000258733
- ENSG00000136235
- ENST00000381990
- ENSP00000371420
- HGFIN
- NMB
- NMB
- HGFIN
- PLCA3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.96 | ||
transcription factor perturbation | 0.88 | ||
small molecule perturbation | 0.85 | ||
virus perturbation | 0.72 | ||
cellular component | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 225.02 (req: < 5)
Gene RIFs: 62 (req: <= 3)
Antibodies: 376 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 225.02 (req: >= 5)
Gene RIFs: 62 (req: > 3)
Antibodies: 376 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (56)
IL31RA
Novelty: 0.00737445
p_int: 0.863767311
p_ni: 0.135952578
p_wrong: 0.000280112
Score: 0.187
Data Source: BioPlex,STRINGDB
TFEB
Family: TF
Novelty: 0.00248413
p_int: 0.827229687
p_ni: 0.171973156
p_wrong: 0.000797156
Score: 0.434
Data Source: BioPlex,STRINGDB
FBXL4
Novelty: 0.04286856
p_int: 0.754173915
p_ni: 0.245825916
p_wrong: 1.69e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | PTK6 promotes HIF1A stabilization | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Non-Receptor Tyrosine Kinases | ||||
Reactome | Signaling by PTK6 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
PTK6 promotes HIF1A stabilization | ||||
Signal Transduction | ||||
Signaling by Non-Receptor Tyrosine Kinases | ||||
Signaling by PTK6 | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Functions (5)
Components (5)
Processes (19)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Mutant Phenotype (IMP) | ParkinsonsUK-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | ParkinsonsUK-UCL | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
3 | 2 | 1 | 1.1 | 81.6 | |||||
C-reactive protein measurement | 1 | 2 | 2 | 66.6 | |||||
1 | 1 | 0 | 3.9 | 36.9 | |||||
electrocardiography | 1 | 1 | 2 | 4.2 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 1.1 | 81.6 | |||||
C-reactive protein measurement | 2 | 66.6 | |||||
0 | 3.9 | 36.9 | |||||
electrocardiography | 2 | 4.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | glycoprotein nmb | VGNC:7386 | 463289 | |||||
Macaque | glycoprotein nmb | 704990 | ||||||
Mouse | MGI:1934765 | 93695 | ||||||
Rat | RGD:71008 | 113955 | ||||||
Dog | glycoprotein nmb | VGNC:41389 | 482355 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | glycoprotein nmb | |||||
Macaque | glycoprotein nmb | |||||
Mouse | ||||||
Rat | ||||||
Dog | glycoprotein nmb | |||||
Publication Statistics
PubMed Score 225.02
PubMed score by year
PubTator Score 92.94
PubTator score by year
Related Publications
Text Mined References (80)
GeneRif Annotations (62)
Items per page:
0 of 0
PMID | Year | Title |
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