Tchem SLC9A5 Sodium/hydrogen exchanger 5

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc9 Family Of Sodium/hydrogen Exchangers / Sodium/hydrogen Exchanger 5

Protein Summary

Description

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity).

Uniprot Accession IDs

• Q14940
• A5PKY7
• Q9Y626

Gene Name

• SLC9A5

Ensembl ID

• ENST00000299798
• ENSP00000299798
• ENSG00000135740

Symbol

• NHE5
• NHE5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.7
transcription factor binding site profile	0.66
transcription factor	0.63
cell line	0.58
protein domain	0.58

Related Tools

RESOLUTE

RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.89   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 54   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.89   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

amiloride

SLC9A5Tchem Transporter

Ki : 4.67999983

Active Ligands (4)

Explore Active Ligands

1 – 4 of 4

ethylisopropylamiloride

SLC9A5Tchem Transporter

Ki : 6.38

5-(N,N-hexamethylene)-amiloride

SLC9A5Tchem Transporter

Ki : 6.43

CHEMBL3892788,CHEMBL3949677

SLC9A5Tchem Transporter

IC50 : 6.54

CHEMBL466311

SLC9A5Tchem Transporter

IC50 : 6.43

GWAS Traits (16)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 16

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	1	4	4		96.2
mean reticulocyte volume	EFO_0010701	1	4	4		94.2
heel bone mineral density	EFO_0009270	3	3	6		93.1
BMI-adjusted waist-hip ratio	EFO_0007788	5	2	5		72.8
BMI-adjusted waist circumference	EFO_0007789	5	5	8		65.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 16

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	4		96.2
mean reticulocyte volume	EFO_0010701	4		94.2
heel bone mineral density	EFO_0009270	6		93.1
BMI-adjusted waist-hip ratio	EFO_0007788	5		72.8
BMI-adjusted waist circumference	EFO_0007789	8		65.7

Reset Zoom  Beta Count   Odds Ratio

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 9 member A5	VGNC:9018	454163
Mouse	solute carrier family 9 (sodium/hydrogen exchanger), member 5	MGI:2685542	277973
Rat	solute carrier family 9 member A5	RGD:620473	192215
Dog	solute carrier family 9 member A5	VGNC:46487	609901
Horse	solute carrier family 9 member A5	VGNC:23281	100053217

Species	Name	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 9 member A5
Mouse	solute carrier family 9 (sodium/hydrogen exchanger), member 5
Rat	solute carrier family 9 member A5
Dog	solute carrier family 9 member A5
Horse	solute carrier family 9 member A5

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q14940-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)

Reactome (4)

SLC-mediated transmembrane transport (R-HSA-425407)

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Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Reactome	Sodium/Proton exchangers	9 targets	R-HSA-425986
Reactome	Transport of inorganic cations/anions and amino acids/oligopeptides	106 targets	R-HSA-425393
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Sodium/Proton exchangers	9 targets	R-HSA-425986
Transport of inorganic cations/anions and amino acids/oligopeptides	106 targets	R-HSA-425393
Transport of small molecules	725 targets	R-HSA-382551

Gene Ontology Terms (8)

Functions (2)

Components (2)

Processes (4)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
potassium:proton antiporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
sodium:proton antiporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (41)

Explore Interacting Targets

1 – 10 of 41

• See Interactions on String-DB

DIRAS1

Tbio

Family:  Enzyme

Novelty:  0.13332903

p_int:  0.999895905

p_ni:  0.000087091

p_wrong:  0.000017004

Data Source:  BioPlex

PRKAA1

Tclin

Family:  Kinase

Novelty:  0.01205826

p_int:  0.998419594

p_ni:  0.001580406

Data Source:  BioPlex

CDKN1A

Tchem

Family:  Enzyme

Novelty:  0.00033009

p_int:  0.994416682

p_ni:  0.005552617

p_wrong:  0.0000307

Data Source:  BioPlex

PRKAB2

Tchem

Family:  Enzyme

Novelty:  0.02815065

p_int:  0.987848738

p_ni:  0.001687595

p_wrong:  0.010463667

Data Source:  BioPlex

PRKAB1

Tchem

Family:  Kinase

Novelty:  0.01610606

p_int:  0.966681723

p_ni:  0.03327468

p_wrong:  0.000043597

Data Source:  BioPlex

RAP1GDS1

Tbio

Family:  Enzyme

Novelty:  0.06140479

p_int:  0.901388221

p_ni:  0.098611779

Data Source:  BioPlex

CHP1

Tbio

Novelty:  0.01299969

Score:  0.871

Data Source:  STRINGDB

SLC9B2

Tbio

Family:  Transporter

Novelty:  0.04898001

Score:  0.811

Data Source:  STRINGDB

SLC9A3R2

Tbio

Family:  Transporter

Novelty:  0.01401705

Score:  0.688

Data Source:  STRINGDB

CALM3

Tclin

Novelty:  0.00461552

Score:  0.678

Data Source:  STRINGDB

Publication Statistics

PubMed Score  20.89

PubMed score by year

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PubTator Score  15.99

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Antiport
Complete proteome
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Reference proteome
Sodium
Sodium transport
Transmembrane

GWAS Trait Find Similar Targets

No Header	No Header
age at onset
apolipoprotein A 1 measurement
balding measurement
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
heel bone mineral density
high density lipoprotein cholesterol measurement
intraocular pressure measurement
mean corpuscular volume
mean reticulocyte volume