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Tchem
SLC9A5
Sodium/hydrogen exchanger 5

Protein Summary
Description
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299798
  • ENSP00000299798
  • ENSG00000135740

Symbol
  • NHE5
  • NHE5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.7
transcription factor binding site profile
0.66
transcription factor
0.63
cell line
0.58
protein domain
0.58


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.89   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.89   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
amiloride
Rendered image for amiloride
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
4
4
96.2
mean reticulocyte volume
1
4
4
94.2
heel bone mineral density
3
3
6
93.1
BMI-adjusted waist-hip ratio
5
2
5
72.8
BMI-adjusted waist circumference
5
5
8
65.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
96.2
mean reticulocyte volume
4
94.2
heel bone mineral density
6
93.1
BMI-adjusted waist-hip ratio
5
72.8
BMI-adjusted waist circumference
8
65.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 9 member A5
VGNC:9018
454163
Mouse
MGI:2685542
277973
Rat
RGD:620473
192215
Dog
solute carrier family 9 member A5
VGNC:46487
609901
Horse
solute carrier family 9 member A5
VGNC:23281
100053217
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 9 member A5
Mouse
Rat
Dog
solute carrier family 9 member A5
Horse
solute carrier family 9 member A5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14940-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Sodium/Proton exchangers
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Sodium/Proton exchangers
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (41)
1 – 10 of 41
DIRAS1
Tbio
Family:  Enzyme
Novelty:  0.13332903
p_int:  0.999895905
p_ni:  0.000087091
p_wrong:  0.000017004
Data Source:  BioPlex
PRKAA1
Tclin
Family:  Kinase
Novelty:  0.01205826
p_int:  0.998419594
p_ni:  0.001580406
Data Source:  BioPlex
CDKN1A
Tchem
Family:  Enzyme
Novelty:  0.00033009
p_int:  0.994416682
p_ni:  0.005552617
p_wrong:  0.0000307
Data Source:  BioPlex
PRKAB2
Tchem
Family:  Enzyme
Novelty:  0.02815065
p_int:  0.987848738
p_ni:  0.001687595
p_wrong:  0.010463667
Data Source:  BioPlex
PRKAB1
Tchem
Family:  Kinase
Novelty:  0.01610606
p_int:  0.966681723
p_ni:  0.03327468
p_wrong:  0.000043597
Data Source:  BioPlex
RAP1GDS1
Tbio
Family:  Enzyme
Novelty:  0.06140479
p_int:  0.901388221
p_ni:  0.098611779
Data Source:  BioPlex
CHP1
Tbio
Novelty:  0.01299969
Score:  0.871
Data Source:  STRINGDB
SLC9B2
Tbio
Family:  Transporter
Novelty:  0.04898001
Score:  0.811
Data Source:  STRINGDB
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
Score:  0.688
Data Source:  STRINGDB
CALM3
Tclin
Novelty:  0.00461552
Score:  0.678
Data Source:  STRINGDB
Publication Statistics
PubMed Score  20.89

PubMed score by year
PubTator Score  15.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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