SLC9A5
Sodium/hydrogen exchanger 5
Protein Summary
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity).
- ENST00000299798
- ENSP00000299798
- ENSG00000135740
- NHE5
- NHE5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.7 | ||
transcription factor binding site profile | 0.66 | ||
transcription factor | 0.63 | ||
cell line | 0.58 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.89 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 54 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.89 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 54 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (4)
Protein-Protein Interactions (41)
DIRAS1
Family: Enzyme
Novelty: 0.13332903
p_int: 0.999895905
p_ni: 0.000087091
p_wrong: 0.000017004
Data Source: BioPlex
PRKAA1
Family: Kinase
Novelty: 0.01205826
p_int: 0.998419594
p_ni: 0.001580406
Data Source: BioPlex
CDKN1A
Family: Enzyme
Novelty: 0.00033009
p_int: 0.994416682
p_ni: 0.005552617
p_wrong: 0.0000307
Data Source: BioPlex
PRKAB2
Family: Enzyme
Novelty: 0.02815065
p_int: 0.987848738
p_ni: 0.001687595
p_wrong: 0.010463667
Data Source: BioPlex
PRKAB1
Family: Kinase
Novelty: 0.01610606
p_int: 0.966681723
p_ni: 0.03327468
p_wrong: 0.000043597
Data Source: BioPlex
RAP1GDS1
Family: Enzyme
Novelty: 0.06140479
p_int: 0.901388221
p_ni: 0.098611779
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | SLC-mediated transmembrane transport | ||||
Reactome | Sodium/Proton exchangers | ||||
Reactome | Transport of inorganic cations/anions and amino acids/oligopeptides | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
SLC-mediated transmembrane transport | ||||
Sodium/Proton exchangers | ||||
Transport of inorganic cations/anions and amino acids/oligopeptides | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (2)
Components (2)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 4 | 4 | 96.2 | |||||
mean reticulocyte volume | 1 | 4 | 4 | 94.2 | |||||
heel bone mineral density | 3 | 3 | 6 | 93.1 | |||||
BMI-adjusted waist-hip ratio | 5 | 2 | 5 | 72.8 | |||||
BMI-adjusted waist circumference | 5 | 5 | 8 | 65.7 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular volume | 4 | 96.2 | |||||
mean reticulocyte volume | 4 | 94.2 | |||||
heel bone mineral density | 6 | 93.1 | |||||
BMI-adjusted waist-hip ratio | 5 | 72.8 | |||||
BMI-adjusted waist circumference | 8 | 65.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | solute carrier family 9 member A5 | VGNC:9018 | 454163 | |||||
Mouse | MGI:2685542 | 277973 | ||||||
Rat | RGD:620473 | 192215 | ||||||
Dog | solute carrier family 9 member A5 | VGNC:46487 | 609901 | |||||
Horse | solute carrier family 9 member A5 | VGNC:23281 | 100053217 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | solute carrier family 9 member A5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 9 member A5 | |||||
Horse | solute carrier family 9 member A5 | |||||
Publication Statistics
PubMed Score 20.89
PubMed score by year
PubTator Score 15.99
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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