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Tbio
NFIX
Nuclear factor 1 X-type

Protein Summary
Description
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397661
  • ENSP00000380781
  • ENSG00000008441
  • ENST00000585575
  • ENSP00000468794
  • ENST00000587260
  • ENSP00000467785
  • ENST00000587760
  • ENSP00000466389
  • ENST00000592199
  • ENSP00000467512

Symbol
  • CTF
  • NF1A
  • NF1-X
  • MRSHSS
  • NF-I/X
  • SOTOS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.95
transcription factor perturbation
0.91
disease perturbation
0.74
protein domain
0.73
biological process
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.96   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.96   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0