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Tbio
NFATC4
Nuclear factor of activated T-cells, cytoplasmic 4

Protein Summary
Description
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons. This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible express ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250373
  • ENSP00000250373
  • ENSG00000100968
  • ENST00000413692
  • ENSP00000388910
  • ENST00000422617
  • ENSP00000396788
  • ENST00000424781
  • ENSP00000388668
  • ENST00000539237
  • ENSP00000439350
  • ENST00000553469
  • ENSP00000451502
  • ENST00000553708
  • ENSP00000450590
  • ENST00000553879
  • ENSP00000452349
  • ENST00000554050
  • ENSP00000451151
  • ENST00000554344
  • ENSP00000450469
  • ENST00000554473
  • ENSP00000450810
  • ENST00000554591
  • ENSP00000452039
  • ENST00000554661
  • ENSP00000450733
  • ENST00000554966
  • ENSP00000450644
  • ENST00000555167
  • ENSP00000451395
  • ENST00000555393
  • ENSP00000451801
  • ENST00000555453
  • ENSP00000450686
  • ENST00000555590
  • ENSP00000451224
  • ENST00000555802
  • ENSP00000451590
  • ENST00000556169
  • ENSP00000451454
  • ENST00000556279
  • ENSP00000452270
  • ENST00000556759
  • ENSP00000451183
  • ENST00000557451
  • ENSP00000451284
  • ENST00000557767
  • ENSP00000451496
  • ENST00000642182
  • ENSP00000495011
  • ENSG00000285485
  • ENST00000642302
  • ENSP00000494405
  • ENST00000642423
  • ENSP00000495052
  • ENST00000642571
  • ENSP00000493808
  • ENST00000642650
  • ENSP00000495758
  • ENST00000643468
  • ENSP00000494577
  • ENST00000643679
  • ENSP00000493557
  • ENST00000643941
  • ENSP00000493733
  • ENST00000644025
  • ENSP00000494705
  • ENST00000644166
  • ENSP00000496192
  • ENST00000644182
  • ENSP00000495766
  • ENST00000644376
  • ENSP00000493885
  • ENST00000644583
  • ENSP00000496733
  • ENST00000644758
  • ENSP00000495684
  • ENST00000645116
  • ENSP00000493851
  • ENST00000645397
  • ENSP00000493943
  • ENST00000645587
  • ENSP00000495213
  • ENST00000645795
  • ENSP00000495926
  • ENST00000646023
  • ENSP00000494993
  • ENST00000646364
  • ENSP00000496579
  • ENST00000646650
  • ENSP00000496777
  • ENST00000646652
  • ENSP00000496108
  • ENST00000647017
  • ENSP00000496558
  • ENST00000647345
  • ENSP00000493614

Symbol
  • NFAT3
  • NFAT3
  • NF-AT3
  • NF-ATC4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
kinase
0.94
molecular function
0.93
transcription factor
0.88
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.53   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 446   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.53   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 446   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
7
3
12
94.9
sex hormone-binding globulin measurement
6
1
6
87.5
alkaline phosphatase measurement
1
1
0
11.2
79.5
apolipoprotein B measurement
1
1
1
75.7
testosterone measurement
3
1
3
75
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
12
94.9
sex hormone-binding globulin measurement
6
87.5
alkaline phosphatase measurement
0
11.2
79.5
apolipoprotein B measurement
1
75.7
testosterone measurement
3
75
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear factor of activated T cells 4
VGNC:9161
452821
Macaque
nuclear factor of activated T-cells 4
714785
Mouse
MGI:1920431
73181
Rat
RGD:1310749
305897
Dog
nuclear factor of activated T cells 4
VGNC:43770
480272
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear factor of activated T cells 4
Macaque
nuclear factor of activated T-cells 4
Mouse
Rat
Dog
nuclear factor of activated T cells 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14934-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Axon guidance
KEGG
Oxytocin signaling pathway
KEGG
Kaposi sarcoma-associated herpesvirus infection
KEGG
Human T-cell leukemia virus 1 infection
KEGG
C-type lectin receptor signaling pathway
Name
Explore in Pharos
Explore in Source
Axon guidance
Oxytocin signaling pathway
Kaposi sarcoma-associated herpesvirus infection
Human T-cell leukemia virus 1 infection
C-type lectin receptor signaling pathway
Gene Ontology Terms (37)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Genetic Interaction (IGI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (59)
1 – 10 of 59
PPP3CC
Tbio
Family:  Enzyme
Novelty:  0.02633046
p_int:  0.999999989
p_ni:  4e-9
p_wrong:  7e-9
Score:  0.717
Data Source:  BioPlex,STRINGDB
PPP3CA
Tchem
Family:  Enzyme
Novelty:  0.00234189
p_int:  0.999999356
p_ni:  6.39e-7
p_wrong:  5e-9
Score:  0.852
Data Source:  BioPlex,STRINGDB
GATA4
Tbio
Family:  TF
Novelty:  0.00094282
Score:  0.964
Data Source:  STRINGDB
PPP3CB
Tbio
Family:  Enzyme
Novelty:  0.02156713
Score:  0.937
Data Source:  STRINGDB
PPP3R1
Tbio
Novelty:  0.00263264
Score:  0.892
Data Source:  STRINGDB
NFATC3
Tbio
Family:  TF
Novelty:  0.00602983
Score:  0.878
Data Source:  STRINGDB
SRF
Tbio
Family:  TF
Novelty:  0.00088839
Score:  0.843
Data Source:  STRINGDB
NFATC2
Tbio
Family:  TF
Novelty:  0.00312526
Score:  0.836
Data Source:  STRINGDB
SOX10
Tbio
Family:  TF
Novelty:  0.00130552
Score:  0.767
Data Source:  STRINGDB
MEF2C
Tbio
Family:  TF
Novelty:  0.00232724
Score:  0.741
Data Source:  STRINGDB
Publication Statistics
PubMed Score  128.53

PubMed score by year
PubTator Score  53.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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