Tdark ZNF169 Zinc finger protein 169

Protein Summary

Description

May be involved in transcriptional regulation.

Uniprot Accession IDs

• Q14929
• A2AGP5
• A8K127
• Q6PI28

Gene Name

• ZNF169

Ensembl ID

• ENST00000395395
• ENSP00000378792
• ENSG00000175787

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.84
tissue sample	0.65
ligand (protein) perturbation	0.59
microRNA	0.59
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Zinc Finger Protein 169

Protein / ... / Krab Box Transcription Factor / Zinc Finger Protein 169

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / Krab Box Transcription Factor / Zinc Finger Protein 169

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.32   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 151   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.32   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (61)

Explore Interacting Targets

1 – 10 of 61

• See Interactions on String-DB

TWNK

Tbio

Novelty:  0.00393371

p_int:  0.999985605

p_ni:  0.000014395

Data Source:  BioPlex

RBAK

Tbio

Family:  TF

Novelty:  0.12597665

p_int:  0.999903058

p_ni:  0.000096887

p_wrong:  5.5e-8

Data Source:  BioPlex

SOGA1

Tbio

Novelty:  0.08349978

p_int:  0.999841558

p_ni:  0.000158441

Data Source:  BioPlex

ZYG11A

Tbio

Novelty:  0.13413639

p_int:  0.99979187

p_ni:  0.000149758

p_wrong:  0.000058373

Data Source:  BioPlex

ZNF92

Tbio

Family:  TF

Novelty:  0.05724663

p_int:  0.999359896

p_ni:  0.000640059

p_wrong:  4.5e-8

Data Source:  BioPlex

SORL1

Tbio

Novelty:  0.00380895

p_int:  0.997490865

p_ni:  0.002509135

Data Source:  BioPlex

ZNF689

Tdark

Family:  TF

Novelty:  1.03726427

p_int:  0.996606053

p_ni:  0.003330066

p_wrong:  0.000063881

Data Source:  BioPlex

ZBTB10

Tbio

Family:  TF

Novelty:  0.05707286

p_int:  0.992685037

p_ni:  0.007153924

p_wrong:  0.000161039

Data Source:  BioPlex

ZNF445

Tdark

Family:  TF

Novelty:  0.43307505

p_int:  0.9924436

p_ni:  0.0075564

Data Source:  BioPlex

TRIM41

Tbio

Family:  Enzyme

Novelty:  0.17238173

p_int:  0.991096804

p_ni:  0.007595608

p_wrong:  0.001307588

Score:  0.152

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

KEGG (1)

Gene expression (Transcription) (R-HSA-74160)

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (3)

Components (1)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean reticulocyte volume	EFO_0010701	1	1	1		79.3
type II diabetes mellitus	EFO_0001360	2	2	1	1	69.1
mean corpuscular volume	EFO_0004526	1	1	1		57.8
body mass index	EFO_0004340	2	2	3		39.5
birth weight	EFO_0004344	1	1	1		27.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean reticulocyte volume	EFO_0010701	1		79.3
type II diabetes mellitus	EFO_0001360	1	1	69.1
mean corpuscular volume	EFO_0004526	1		57.8
body mass index	EFO_0004340	3		39.5
birth weight	EFO_0004344	1		27.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
DNA-binding
Metal-binding
Nucleus
Polymorphism
Reference proteome
Repeat
Transcription
Transcription regulation
Zinc

GWAS Trait Find Similar Targets

No Header	No Header
birth weight
body height at birth
body mass index
mean corpuscular volume
mean reticulocyte volume
type II diabetes mellitus

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 169	VGNC:4905	465246
Macaque	zinc finger protein 169		718203
Mouse	zinc finger protein 169	MGI:1915161	67911
Rat	zinc finger protein 169	RGD:1304631	306816
Dog	zinc finger protein 169	VGNC:48665	484204

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 169
Macaque	zinc finger protein 169
Mouse	zinc finger protein 169
Rat	zinc finger protein 169
Dog	zinc finger protein 169

Publication Statistics

PubMed Score 1.32

PubMed score by year

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PubTator Score 1.67

PubTator score by year

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Related Publications

Text Mined References (11)

Items per page:

10

0 of 0

PMID	Year	Title