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Tbio
DRAP1
Dr1-associated corepressor

Protein Summary
Description
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enha ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312515
  • ENSP00000307850
  • ENSG00000175550

Symbol
  • NC2-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
disease perturbation
0.83
tissue sample
0.71
co-expressed gene
0.69
transcription factor
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.49   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.49   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
DR1
Tbio
Novelty:  0.00138571
p_int:  0.999999906
p_ni:  9.4e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
MRPS11
Tdark
Novelty:  0.29449255
p_int:  0.998377195
p_ni:  0.000153925
p_wrong:  0.00146888
Score:  0.187
Data Source:  BioPlex,STRINGDB
POLE3
Tbio
Family:  Enzyme
Novelty:  0.09657513
p_int:  0.994629965
p_ni:  0.005364738
p_wrong:  0.000005298
Score:  0.533
Data Source:  BioPlex,STRINGDB
FOXH1
Tbio
Family:  TF
Novelty:  0.00823939
Score:  0.984
Data Source:  Reactome,STRINGDB
TBP
Tbio
Novelty:  0.00034941
Score:  0.943
Data Source:  STRINGDB
SMAD2
Tbio
Family:  TF
Novelty:  0.00040166
Score:  0.94
Data Source:  STRINGDB
SMAD4
Tbio
Family:  TF
Novelty:  0.00047069
Score:  0.926
Data Source:  STRINGDB
SMAD3
Tchem
Family:  TF
Novelty:  0.00048058
Score:  0.902
Data Source:  STRINGDB
BTAF1
Tbio
Novelty:  0.01586704
Score:  0.867
Data Source:  STRINGDB
TBPL2
Tbio
Novelty:  0.01299173
Score:  0.843
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Signal Transduction
Reactome
Signaling by Activin
Reactome
Signaling by NODAL
Reactome
Signaling by TGF-beta family members
Name
Explore in Pharos
Explore in Source
Developmental Biology
Signal Transduction
Signaling by Activin
Signaling by NODAL
Signaling by TGF-beta family members
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Model (ISM)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
2
3
93.7
eosinophil percentage of leukocytes
2
2
2
91.6
uric acid measurement
2
2
2
89.6
BMI-adjusted waist circumference
1
4
4
81.1
myeloid white cell count
1
1
1
77
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
93.7
eosinophil percentage of leukocytes
2
91.6
uric acid measurement
2
89.6
BMI-adjusted waist circumference
4
81.1
myeloid white cell count
1
77
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DR1 associated protein 1
VGNC:6753
451337
Macaque
DR1 associated protein 1
715271
Mouse
MGI:1913806
66556
Rat
RGD:1308477
293674
Horse
DR1 associated protein 1
VGNC:17311
100051992
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DR1 associated protein 1
Macaque
DR1 associated protein 1
Mouse
Rat
Horse
DR1 associated protein 1
Publication Statistics
PubMed Score 15.49
PubMed score by year
PubTator Score 13.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title