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Tbio
PTGR1
Prostaglandin reductase 1

Protein Summary
Description
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4. This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309195
  • ENSP00000311572
  • ENSG00000106853
  • ENST00000407693
  • ENSP00000385763
  • ENST00000538962
  • ENSP00000440281

Symbol
  • LTB4DH
  • PGR1
  • ZADH3
  • LTB4DH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.9
small molecule perturbation
0.88
gene perturbation
0.76
cell type or tissue
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.33   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.33   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
puberty onset measurement
1
1
1
41.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
puberty onset measurement
1
41.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prostaglandin reductase 1 pseudogene
467369
Macaque
prostaglandin reductase 1
708725
Mouse
MGI:1914353
67103
Rat
RGD:621195
192227
Dog
prostaglandin reductase 1
VGNC:45150
474802
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prostaglandin reductase 1 pseudogene
Macaque
prostaglandin reductase 1
Mouse
Rat
Dog
prostaglandin reductase 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14914-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biosynthesis of specialized proresolving mediators (SPMs)
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biosynthesis of specialized proresolving mediators (SPMs)
Fatty acid metabolism
Metabolism
Metabolism of lipids
Protein-Protein Interactions (44)
1 – 10 of 44
PRDX6
Tbio
Novelty: 0.00180564
Score: 0.691
Data Source: STRINGDB
ADH5
Tchem
Family: Enzyme
Novelty: 0.00248968
Score: 0.642
Data Source: STRINGDB
SRXN1
Tbio
Novelty: 0.00780861
Score: 0.637
Data Source: STRINGDB
LTA4H
Tchem
Family: Enzyme
Novelty: 0.00505614
Score: 0.59
Data Source: STRINGDB
BPIFB2
Tdark
Novelty: 0.2051039
Score: 0.556
Data Source: STRINGDB
AKR1A1
Tchem
Family: Enzyme
Novelty: 0.0054436
Score: 0.536
Data Source: STRINGDB
TXNRD1
Tclin
Family: Enzyme
Novelty: 0.00299018
Score: 0.51
Data Source: STRINGDB
TXN
Tchem
Novelty: 0.00048949
Score: 0.506
Data Source: STRINGDB
SULT4A1
Tbio
Family: Enzyme
Novelty: 0.02455678
Score: 0.505
Data Source: STRINGDB
YLPM1
Tdark
Novelty: 0.26435727
Score: 0.495
Data Source: STRINGDB
Publication Statistics
PubMed Score  38.33

PubMed score by year
PubTator Score  22.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer