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Tbio
MYBPC3
Myosin-binding protein C, cardiac-type

Protein Summary
Description
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000545968
  • ENSP00000442795
  • ENSG00000134571

Symbol
  • FHC
  • CMH4
  • CMD1MM
  • LVNC10
  • MYBP-C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.85
protein domain
0.85
cell type or tissue
0.76
biological term
0.74
gene perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 370.81   (req: < 5)
Gene RIFs: 140   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 370.81   (req: >= 5)
Gene RIFs: 140   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
94.8
intraocular pressure measurement
2
1
2
87
mathematical ability
1
1
1
82
high density lipoprotein cholesterol measurement
3
2
5
78.5
mean platelet volume
1
1
1
73
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
94.8
intraocular pressure measurement
2
87
mathematical ability
1
82
high density lipoprotein cholesterol measurement
5
78.5
mean platelet volume
1
73
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin binding protein C, cardiac
451168
Macaque
myosin binding protein C, cardiac
712093
Mouse
MGI:102844
17868
Rat
RGD:1305950
295929
Dog
myosin binding protein C, cardiac
VGNC:43524
483624
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin binding protein C, cardiac
Macaque
myosin binding protein C, cardiac
Mouse
Rat
Dog
myosin binding protein C, cardiac
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Gene Ontology Terms (33)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (126)
1 – 10 of 126
MYH6
Tbio
Novelty: 0.00058671
Score: 0.992
Data Source: Reactome,STRINGDB
TNNT2
Tbio
Novelty: 0.00044568
Score: 0.992
Data Source: STRINGDB
TNNI3
Tbio
Novelty: 0.00020053
Score: 0.986
Data Source: STRINGDB
MYH7
Tbio
Novelty: 0.00268092
Score: 0.986
Data Source: STRINGDB
MYL2
Tbio
Novelty: 0.0018887
Score: 0.983
Data Source: Reactome,STRINGDB
MYL3
Tbio
Novelty: 0.00493817
Score: 0.981
Data Source: Reactome,STRINGDB
TPM1
Tbio
Novelty: 0.00261206
Score: 0.98
Data Source: STRINGDB
TCAP
Tbio
Novelty: 0.00623581
Score: 0.97
Data Source: STRINGDB
ACTN2
Tbio
Novelty: 0.00615882
Score: 0.964
Data Source: STRINGDB
TTN
Tbio
Family: Kinase
Novelty: 0.00040356
Score: 0.963
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  370.81

PubMed score by year
PubTator Score  302.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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