Tbio CRYM Ketimine reductase mu-crystallin

Protein Summary

Description

Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors. Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• Q14894
• D5MNX0
• Q5HYB7

Gene Name

• CRYM

Ensembl ID

• ENST00000219599
• ENSP00000219599
• ENSG00000103316
• ENST00000543948
• ENSP00000440227
• ENST00000639592
• ENSP00000490961
• ENSG00000283922
• ENST00000640547
• ENSP00000492104

Symbol

• THBP
• THBP
• DFNA40

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.85
molecular function	0.84
PubMedID	0.8
tissue sample	0.69
disease perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Lyase / Ketimine Reductase Mu-crystallin

DTO Classes

Protein / Enzyme / Lyase / Ketimine Reductase Mu-crystallin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.38   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 289   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.38   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0