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Tbio
MTF1
Metal regulatory transcription factor 1

Protein Summary
Description
Activates the metallothionein I promoter. Binds to the metal responsive element (MRE). This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373036
  • ENSP00000362127
  • ENSG00000188786

Symbol
  • ZRF
  • MTF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
transcription factor perturbation
0.94
virus perturbation
0.9
disease perturbation
0.87
histone modification site profile
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.28   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.28   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
54.4
2
1
2
1.1
53.7
mathematical ability
3
2
3
53.2
pulse pressure measurement
1
1
2
50.6
Thyroid preparation use measurement
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
54.4
2
1.1
53.7
mathematical ability
3
53.2
pulse pressure measurement
2
50.6
Thyroid preparation use measurement
1
48.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
metal regulatory transcription factor 1
VGNC:12751
456766
Macaque
metal regulatory transcription factor 1
714795
Mouse
MGI:101786
17764
Rat
RGD:1308956
362591
Dog
metal regulatory transcription factor 1
VGNC:43466
608127
Species
Name
OMA
EggNOG
Inparanoid
Chimp
metal regulatory transcription factor 1
Macaque
metal regulatory transcription factor 1
Mouse
Rat
Dog
metal regulatory transcription factor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14872-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (97)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Cellular responses to external stimuli
Reactome
MTF1 activates gene expression
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Cellular responses to external stimuli
MTF1 activates gene expression
Metabolism
Metabolism of lipids
Gene Ontology Terms (17)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (43)
1 – 10 of 43
CSRP1
Tbio
Novelty:  0.01976527
Score:  0.908
Data Source:  STRINGDB
MT1M
Tbio
Novelty:  0.02649699
Score:  0.901
Data Source:  STRINGDB
MT1HL1
Tdark
Novelty:  1.63453786
Score:  0.901
Data Source:  STRINGDB
SNCB
Tbio
Novelty:  0.00743454
Score:  0.9
Data Source:  STRINGDB
SLC30A1
Tbio
Family:  Transporter
Novelty:  0.00528427
Score:  0.839
Data Source:  STRINGDB
MT4
Tbio
Novelty:  0.03546777
Score:  0.8
Data Source:  STRINGDB
MT3
Tbio
Novelty:  0.00321947
Score:  0.755
Data Source:  STRINGDB
MT1H
Tbio
Novelty:  0.01220609
Score:  0.748
Data Source:  STRINGDB
MT1X
Tbio
Novelty:  0.03005906
Score:  0.748
Data Source:  STRINGDB
MT1B
Tbio
Novelty:  0.03802803
Score:  0.748
Data Source:  STRINGDB
Publication Statistics
PubMed Score  81.28

PubMed score by year
PubTator Score  103.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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