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Tbio
ARID5B
AT-rich interactive domain-containing protein 5B

Protein Summary
Description
Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279873
  • ENSP00000279873
  • ENSG00000150347
  • ENST00000309334
  • ENSP00000308862

Symbol
  • DESRT
  • MRF2
  • MRF2
  • DESRT
  • MRF-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
PubMedID
0.95
disease perturbation
0.87
phenotype
0.87
gene perturbation
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.61   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.61   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
3
0
1.6
99.6
smoking status measurement
2
2
2
97.7
B-cell acute lymphoblastic leukemia
2
2
0
1.8
96
4
3
3
1.2
93.2
intraocular pressure measurement
2
3
3
88.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
99.6
smoking status measurement
2
97.7
B-cell acute lymphoblastic leukemia
0
1.8
96
3
1.2
93.2
intraocular pressure measurement
3
88.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
AT-rich interaction domain 5B
698639
Mouse
MGI:2175912
71371
Dog
AT-rich interaction domain 5B
VGNC:38101
479217
Horse
AT-rich interaction domain 5B
VGNC:15505
100072374
Cow
AT-rich interaction domain 5B
VGNC:26132
783538
Species
Name
OMA
EggNOG
Inparanoid
Macaque
AT-rich interaction domain 5B
Mouse
Dog
AT-rich interaction domain 5B
Horse
AT-rich interaction domain 5B
Cow
AT-rich interaction domain 5B
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14865-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HDMs demethylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HDMs demethylate histones
Gene Ontology Terms (31)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GDB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (43)
1 – 10 of 43
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.999999348
p_ni: 6.51e-7
Score: 0.646
Data Source: BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
p_int: 0.999999127
p_ni: 8.73e-7
Score: 0.71
Data Source: BioPlex,STRINGDB
C16orf87
Tdark
Novelty: 5.71664261
p_int: 0.999998756
p_ni: 0.000001244
Score: 0.891
Data Source: BioPlex,STRINGDB
H2AFZ
Tbio
Novelty: 0.00222512
p_int: 0.999998383
p_ni: 0.000001611
p_wrong: 6e-9
Data Source: BioPlex
THSD4
Tbio
Novelty: 0.12898073
p_int: 0.840069595
p_ni: 0.15992997
p_wrong: 4.34e-7
Score: 0.188
Data Source: BioPlex,STRINGDB
PHF2
Tbio
Family: Epigenetic
Novelty: 0.10427439
Score: 0.956
Data Source: Reactome,STRINGDB
CEBPE
Tbio
Family: TF
Novelty: 0.01183291
Score: 0.738
Data Source: STRINGDB
IKZF1
Tbio
Family: TF
Novelty: 0.0016117
Score: 0.679
Data Source: STRINGDB
PIP4K2A
Tbio
Family: Kinase
Novelty: 0.01130885
Score: 0.677
Data Source: STRINGDB
ZFAND4
Tdark
Novelty: 0.22188427
Score: 0.625
Data Source: STRINGDB
Publication Statistics
PubMed Score  87.61

PubMed score by year
PubTator Score  45.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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