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Tbio
STARD3
StAR-related lipid transfer protein 3

Protein Summary
Description
Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutei ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336308
  • ENSP00000337446
  • ENSG00000131748
  • ENST00000394250
  • ENSP00000377794
  • ENST00000544210
  • ENSP00000439869

Symbol
  • CAB1
  • MLN64
  • CAB1
  • es64
  • MLN64
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
transcription factor
0.7
cellular component
0.68
disease perturbation
0.68
transcription factor binding site profile
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.45   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.45   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
7
5
13
96.9
2
2
0
1.1
75.8
smoking status measurement
1
1
1
70.2
apolipoprotein A 1 measurement
1
1
1
62.5
alcohol drinking
1
1
2
44.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
13
96.9
0
1.1
75.8
smoking status measurement
1
70.2
apolipoprotein A 1 measurement
1
62.5
alcohol drinking
2
44.7
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
StAR related lipid transfer domain containing 3
VGNC:9662
468231
Macaque
StAR related lipid transfer domain containing 3
697212
Mouse
MGI:1929618
59045
Rat
RGD:1549768
363675
Dog
StAR related lipid transfer domain containing 3
VGNC:46882
491024
Species
Name
OMA
EggNOG
Inparanoid
Chimp
StAR related lipid transfer domain containing 3
Macaque
StAR related lipid transfer domain containing 3
Mouse
Rat
Dog
StAR related lipid transfer domain containing 3
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14849-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroid hormones
Reactome
Metabolism of steroids
Reactome
Pregnenolone biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Metabolism of steroid hormones
Metabolism of steroids
Pregnenolone biosynthesis
Protein-Protein Interactions (79)
1 – 10 of 79
CBARP
Tbio
Novelty: 0.04783435
p_int: 0.979938297
p_ni: 0.02005983
p_wrong: 0.000001873
Score: 0.188
Data Source: BioPlex,STRINGDB
MME
Tclin
Family: Enzyme
Novelty: 0.00019144
p_int: 0.976399229
p_ni: 0.023600544
p_wrong: 2.27e-7
Score: 0.152
Data Source: BioPlex,STRINGDB
P2RX2
Tchem
Family: IC
Novelty: 0.00241146
p_int: 0.970308203
p_ni: 0.029691608
p_wrong: 1.89e-7
Data Source: BioPlex
SLC15A1
Tchem
Family: Transporter
Novelty: 0.00149723
p_int: 0.965004035
p_ni: 0.034995934
p_wrong: 3.1e-8
Data Source: BioPlex
CHRM3
Tclin
Family: GPCR
Novelty: 0.00849776
p_int: 0.954153556
p_ni: 0.045846434
p_wrong: 1.1e-8
Data Source: BioPlex
SDF4
Tbio
Novelty: 0.00105893
p_int: 0.953954263
p_ni: 0.045733608
p_wrong: 0.000312129
Score: 0.172
Data Source: BioPlex,STRINGDB
STK36
Tbio
Family: Kinase
Novelty: 0.0963277
p_int: 0.952440075
p_ni: 0.047531365
p_wrong: 0.00002856
Data Source: BioPlex
ERGIC3
Tbio
Novelty: 0.11095443
p_int: 0.947173808
p_ni: 0.052826189
p_wrong: 4e-9
Data Source: BioPlex
MANSC1
Tdark
Novelty: 0.91681036
p_int: 0.912406594
p_ni: 0.087593406
Data Source: BioPlex
PMEL
Tbio
Novelty: 0.00116525
p_int: 0.897913065
p_ni: 0.102086935
Data Source: BioPlex
Publication Statistics
PubMed Score  60.45

PubMed score by year
PubTator Score  47.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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