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Tchem
CHD4
Chromodomain-helicase-DNA-binding protein 4

Protein Summary
Description
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000544040
  • ENSP00000440542
  • ENSG00000111642
  • ENST00000645095
  • ENSP00000496634

Symbol
  • CHD-4
  • Mi-2b
  • SIHIWES
  • Mi2-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
drug perturbation
0.99
disease perturbation
0.98
protein complex
0.98


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.96   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 306   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.96   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (289)
ZNF219
Tbio
Family:  TF
Novelty:  0.17515242
p_int:  0.999999258
p_ni:  7.42e-7
Score:  0.746
Data Source:  BioPlex,STRINGDB
MBD3L1
Tbio
Novelty:  0.11297566
p_int:  0.999996539
p_ni:  0.000003461
Score:  0.865
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999982134
p_ni:  0.000017866
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDK2AP1
Tbio
Family:  Enzyme
Novelty:  0.01584718
p_int:  0.999978719
p_ni:  0.000021282
Score:  0.691
Data Source:  BioPlex,STRINGDB
GATAD2B
Tbio
Family:  TF
Novelty:  0.056775
p_int:  0.999975711
p_ni:  0.000024289
Score:  0.994
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999969773
p_ni:  0.000030227
Score:  0.997
Data Source:  BioPlex,STRINGDB
GATAD2A
Tbio
Novelty:  0.05599551
p_int:  0.999969505
p_ni:  0.000030495
Score:  0.998
Data Source:  BioPlex,STRINGDB
PHF20L1
Tbio
Family:  Epigenetic
Novelty:  0.23101523
p_int:  0.999758906
p_ni:  0.000241094
Score:  0.839
Data Source:  BioPlex,STRINGDB
IKZF1
Tbio
Family:  TF
Novelty:  0.0016117
p_int:  0.997885921
p_ni:  0.002114079
Score:  0.736
Data Source:  BioPlex,STRINGDB
HSFY1
Tdark
Family:  TF
p_int:  0.994893853
p_ni:  0.005106147
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (290)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
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1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
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Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
67.1
mean corpuscular volume
1
1
1
57.3
red blood cell distribution width
1
1
1
56.8
triglyceride measurement
1
1
1
53.3
heel bone mineral density
2
2
2
47.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
67.1
mean corpuscular volume
1
57.3
red blood cell distribution width
1
56.8
triglyceride measurement
1
53.3
heel bone mineral density
2
47.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromodomain helicase DNA binding protein 4
VGNC:51251
451788
Macaque
chromodomain helicase DNA binding protein 4
713162
Mouse
MGI:1344380
107932
Rat
RGD:620064
117535
Dog
chromodomain helicase DNA binding protein 4
VGNC:39202
477714
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromodomain helicase DNA binding protein 4
Macaque
chromodomain helicase DNA binding protein 4
Mouse
Rat
Dog
chromodomain helicase DNA binding protein 4
Publication Statistics
PubMed Score 136.96
PubMed score by year
PubTator Score 72.08
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title