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Tchem
GRM4
Metabotropic glutamate receptor 4

Protein Summary
Description
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374177
  • ENSP00000363292
  • ENSG00000124493
  • ENST00000455714
  • ENSP00000398456
  • ENST00000535756
  • ENSP00000437925
  • ENST00000538487
  • ENSP00000440556
  • ENST00000544773
  • ENSP00000437730
  • ENST00000609222
  • ENSP00000477466

Symbol
  • GPRC1D
  • MGLUR4
  • mGlu4
  • GPRC1D
  • MGLUR4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
ligand (chemical)
0.9
co-expressed gene
0.87
biological process
0.73
cellular component
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.04   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.04   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 126
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dexfosfoserine
Rendered image for dexfosfoserine
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
13
43
51
8.8
99.7
BMI-adjusted waist circumference
7
16
29
99.3
BMI-adjusted waist-hip ratio
6
12
14
99.2
waist-hip ratio
4
11
13
99
waist circumference
2
7
7
98.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
51
8.8
99.7
BMI-adjusted waist circumference
29
99.3
BMI-adjusted waist-hip ratio
14
99.2
waist-hip ratio
13
99
waist circumference
7
98.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate metabotropic receptor 4
VGNC:12786
471986
Macaque
glutamate metabotropic receptor 4
718489
Mouse
MGI:1351341
268934
Dog
glutamate metabotropic receptor 4
VGNC:41511
481749
Horse
glutamate metabotropic receptor 4
VGNC:18602
100061879
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate metabotropic receptor 4
Macaque
glutamate metabotropic receptor 4
Mouse
Dog
glutamate metabotropic receptor 4
Horse
glutamate metabotropic receptor 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14833-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (25)
Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (297)
1 – 10 of 297
HRH3
Tclin
Family:  GPCR
Novelty:  0.00148904
Score:  0.949
Data Source:  STRINGDB
HTR1A
Tclin
Family:  GPCR
Novelty:  0.00015658
Score:  0.946
Data Source:  STRINGDB
DRD2
Tclin
Family:  GPCR
Novelty:  0.00033797
Score:  0.943
Data Source:  STRINGDB
CNR1
Tclin
Family:  GPCR
Novelty:  0.00060063
Score:  0.941
Data Source:  STRINGDB
ADORA1
Tclin
Family:  GPCR
Novelty:  0.00043697
Score:  0.941
Data Source:  STRINGDB
HTR5A
Tchem
Family:  GPCR
Novelty:  0.0160551
Score:  0.937
Data Source:  STRINGDB
DRD3
Tclin
Family:  GPCR
Novelty:  0.00230028
Score:  0.934
Data Source:  STRINGDB
TAS2R40
Tchem
Family:  GPCR
Novelty:  0.61332466
Score:  0.934
Data Source:  STRINGDB
GABBR1
Tclin
Family:  GPCR
Novelty:  0.00086493
Score:  0.933
Data Source:  STRINGDB
TAS2R4
Tchem
Family:  GPCR
Novelty:  0.02938385
Score:  0.933
Data Source:  STRINGDB
Publication Statistics
PubMed Score  276.04

PubMed score by year
PubTator Score  39.96

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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