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Tchem
GRM3
Metabotropic glutamate receptor 3

Protein Summary
Description
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361669
  • ENSP00000355316
  • ENSG00000198822
  • ENST00000439827
  • ENSP00000398767

Symbol
  • GPRC1C
  • MGLUR3
  • GLUR3
  • mGlu3
  • GPRC1C
  • MGLUR3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
ligand (chemical)
0.74
cell line
0.61
disease
0.57
biological process
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.35   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 355   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.35   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 355   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 77
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
glutamic acid
Rendered image for glutamic acid
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
4
5
88.2
10
3
4
1.1
72.7
self reported educational attainment
2
2
2
68.2
cognitive function measurement
1
2
2
53.6
1
1
0
1.1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
5
88.2
4
1.1
72.7
self reported educational attainment
2
68.2
cognitive function measurement
2
53.6
0
1.1
44.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate metabotropic receptor 3
VGNC:4381
746019
Macaque
glutamate metabotropic receptor 3
706645
Mouse
MGI:1351340
108069
Rat
RGD:2744
24416
Dog
glutamate metabotropic receptor 3
VGNC:41510
100683236
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate metabotropic receptor 3
Macaque
glutamate metabotropic receptor 3
Mouse
Rat
Dog
glutamate metabotropic receptor 3
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14832-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (26)
Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Gene Ontology Terms (17)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (329)
1 – 10 of 329
ADCY8
Tchem
Family:  Enzyme
Novelty:  0.00510386
Score:  0.981
Data Source:  STRINGDB
DRD2
Tclin
Family:  GPCR
Novelty:  0.00033797
Score:  0.958
Data Source:  STRINGDB
HTR1A
Tclin
Family:  GPCR
Novelty:  0.00015658
Score:  0.947
Data Source:  STRINGDB
HRH3
Tclin
Family:  GPCR
Novelty:  0.00148904
Score:  0.945
Data Source:  STRINGDB
DRD4
Tchem
Family:  GPCR
Novelty:  0.00099622
Score:  0.943
Data Source:  STRINGDB
DRD3
Tclin
Family:  GPCR
Novelty:  0.00230028
Score:  0.943
Data Source:  STRINGDB
HTR5A
Tchem
Family:  GPCR
Novelty:  0.0160551
Score:  0.943
Data Source:  STRINGDB
GABBR2
Tclin
Family:  GPCR
Novelty:  0.00739771
Score:  0.941
Data Source:  STRINGDB
CNR1
Tclin
Family:  GPCR
Novelty:  0.00060063
Score:  0.94
Data Source:  STRINGDB
ADCY2
Tbio
Family:  Enzyme
Novelty:  0.01649836
Score:  0.936
Data Source:  STRINGDB
Publication Statistics
PubMed Score  267.35

PubMed score by year
PubTator Score  76

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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