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Tchem
GRM7
Metabotropic glutamate receptor 7

Protein Summary
Description
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Gro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357716
  • ENSP00000350348
  • ENSG00000196277
  • ENST00000389335
  • ENSP00000373986
  • ENST00000389336
  • ENSP00000373987
  • ENST00000467425
  • ENSP00000419835
  • ENST00000486284
  • ENSP00000417536

Symbol
  • GPRC1G
  • MGLUR7
  • GLUR7
  • MGLU7
  • GPRC1G
  • MGLUR7
  • PPP1R87
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
trait
1
protein domain
0.97
biological process
0.85
cell type or tissue
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.52   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 398   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.52   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 398   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
50.2
albuminuria
1
1
0
26.4
46.2
diastolic blood pressure
1
1
1
24.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
50.2
albuminuria
0
26.4
46.2
diastolic blood pressure
1
24.3
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate metabotropic receptor 7
VGNC:10041
460140
Macaque
glutamate metabotropic receptor 7
702731
Mouse
MGI:1351344
108073
Rat
RGD:619857
81672
Dog
glutamate metabotropic receptor 7
VGNC:41514
484674
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate metabotropic receptor 7
Macaque
glutamate metabotropic receptor 7
Mouse
Rat
Dog
glutamate metabotropic receptor 7
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14831-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Gene Ontology Terms (28)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (292)
1 – 10 of 292
DRD2
Tclin
Family: GPCR
Novelty: 0.00033797
Score: 0.945
Data Source: STRINGDB
DRD4
Tchem
Family: GPCR
Novelty: 0.00099622
Score: 0.937
Data Source: STRINGDB
HTR1A
Tclin
Family: GPCR
Novelty: 0.00015658
Score: 0.937
Data Source: STRINGDB
SSTR5
Tclin
Family: GPCR
Novelty: 0.00568309
Score: 0.934
Data Source: STRINGDB
CNR1
Tclin
Family: GPCR
Novelty: 0.00060063
Score: 0.933
Data Source: STRINGDB
GNB3
Tbio
Novelty: 0.0037117
Score: 0.933
Data Source: STRINGDB
OPRD1
Tclin
Family: GPCR
Novelty: 0.00757692
Score: 0.932
Data Source: STRINGDB
HRH3
Tclin
Family: GPCR
Novelty: 0.00148904
Score: 0.93
Data Source: STRINGDB
DRD3
Tclin
Family: GPCR
Novelty: 0.00230028
Score: 0.929
Data Source: STRINGDB
GABBR1
Tclin
Family: GPCR
Novelty: 0.00086493
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  261.52

PubMed score by year
PubTator Score  63.22

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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