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Tbio
MEF2D
Myocyte-specific enhancer factor 2D

Protein Summary
Description
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in l ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348159
  • ENSP00000271555
  • ENSG00000116604
  • ENST00000360595
  • ENSP00000353803
  • ENST00000464356
  • ENSP00000476788
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
transcription factor binding site profile
0.97
transcription factor perturbation
0.88
hub protein
0.85
PubMedID
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.34   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 408   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.34   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 408   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (121)
1 – 10 of 121
MEF2B
Tbio
Family:  TF
Novelty:  0.03094093
p_int:  0.999999974
p_ni:  9e-9
p_wrong:  1.7e-8
Score:  0.172
Data Source:  BioPlex,STRINGDB
WRAP53
Tbio
Family:  Enzyme
Novelty:  0.0204638
p_int:  0.99999902
p_ni:  9.73e-7
p_wrong:  8e-9
Data Source:  BioPlex
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
p_int:  0.994952324
p_ni:  0.000004268
p_wrong:  0.005043408
Score:  0.959
Data Source:  BioPlex,STRINGDB
CABIN1
Tbio
Novelty:  0.02528794
Score:  0.99
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.988
Data Source:  STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.981
Data Source:  STRINGDB
MYOG
Tbio
Family:  TF
Novelty:  0.00074867
Score:  0.98
Data Source:  STRINGDB
HDAC5
Tclin
Family:  Epigenetic
Novelty:  0.00484422
Score:  0.979
Data Source:  STRINGDB
MYOD1
Tbio
Family:  TF
Novelty:  0.00053412
Score:  0.978
Data Source:  STRINGDB
MAPK7
Tchem
Family:  Kinase
Novelty:  0.00257226
Score:  0.977
Data Source:  STRINGDB
Pathways (23)
Circadian Clock (R-HSA-400253)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Circadian Clock
Reactome
Developmental Biology
Reactome
Mitochondrial biogenesis
Reactome
Myogenesis
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Circadian Clock
Developmental Biology
Mitochondrial biogenesis
Myogenesis
Organelle biogenesis and maintenance
Gene Ontology Terms (25)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
91.8
4
4
0
1.1
90.6
platelet count
2
2
2
81.2
TPE interval measurement
1
1
3
79.6
BMI-adjusted waist circumference
2
5
5
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
91.8
0
1.1
90.6
platelet count
2
81.2
TPE interval measurement
3
79.6
BMI-adjusted waist circumference
5
70.2
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myocyte enhancer factor 2D
VGNC:1316
457396
Macaque
myocyte enhancer factor 2D
718449
Mouse
MGI:99533
17261
Rat
RGD:621489
81518
Dog
myocyte enhancer factor 2D
VGNC:43145
490413
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myocyte enhancer factor 2D
Macaque
myocyte enhancer factor 2D
Mouse
Rat
Dog
myocyte enhancer factor 2D
Publication Statistics
PubMed Score 154.34
PubMed score by year
PubTator Score 53.29
PubTator score by year