Tbio FXYD3 FXYD domain-containing ion transport regulator 3

Protein Summary

Description

Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:17077088). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (PubMed:7836447). Isoform 1: Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials. Isoform 2: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials. This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q14802
• A6NDE0
• C9JDU2
• F5H174
• F8WB34
• Q13211
• Q6IB59

Gene Name

• FXYD3

Ensembl ID

• ENST00000344013
• ENSP00000339499
• ENSG00000089356
• ENST00000346446
• ENSP00000328259
• ENST00000435734
• ENSP00000389770
• ENST00000603181
• ENSP00000474851
• ENST00000603449
• ENSP00000474055
• ENST00000604255
• ENSP00000473929
• ENST00000604404
• ENSP00000474438
• ENST00000604621
• ENSP00000474526
• ENST00000605552
• ENSP00000474855
• ENST00000605677
• ENSP00000474622

Symbol

• MAT8
• PLML
• MAT8
• PLML

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.85
transcription factor perturbation	0.8
virus perturbation	0.79
molecular function	0.76
phenotype	0.59

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Fxyd Domain-containing Ion Transport Regulator 3

Protein / Enzyme Modulator / Fxyd Domain-containing Ion Transport Regulator 3

DTO Classes

Protein / Ion Channel / Fxyd Family / Fxyd Domain-containing Ion Transport Regulator 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.92   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 131   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.92   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0