Tbio NAA30 N-alpha-acetyltransferase 30

Protein Summary

Description

Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate.

Uniprot Accession IDs

• Q147X3
• Q0IIN2

Gene Name

• NAA30

Ensembl ID

• ENST00000556492
• ENSP00000452521
• ENSG00000139977

Symbol

• C14orf35
• MAK3
• NAT12
• MAK3
• Mak3p
• NAT12
• NAT12P
• C14orf35

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.92
transcription factor perturbation	0.88
co-expressed gene	0.85
microRNA	0.72
histone modification site profile	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.71   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 68   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.71   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0