Protein Summary
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex. This gene encodes a member of the cysteine-aspartic acid prote ...more
- ENST00000264274
- ENSP00000264274
- ENSG00000064012
- ENST00000264275
- ENSP00000264275
- ENST00000323492
- ENSP00000325722
- ENST00000358485
- ENSP00000351273
- ENST00000392258
- ENSP00000376087
- ENST00000392263
- ENSP00000376091
- ENST00000432109
- ENSP00000412523
- MCH5
- CAP4
- MACH
- MCH5
- FLICE
- ALPS2B
- Casp-8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
chemical | 1 | ||
hub protein | 1 | ||
protein domain | 0.97 | ||
protein complex | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3840.67 (req: < 5)
Gene RIFs: 519 (req: <= 3)
Antibodies: 1364 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3840.67 (req: >= 5)
Gene RIFs: 519 (req: > 3)
Antibodies: 1364 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 52
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 198
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (198)
Protein-Protein Interactions (418)
FAS
Novelty: 0.00043286
p_int: 0.999999548
p_ni: 4.5e-7
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
TNFRSF10A
Novelty: 0.0003383
p_int: 0.999999361
p_ni: 6.25e-7
p_wrong: 1.4e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
TNFRSF10B
Novelty: 0.00054433
p_int: 0.999999353
p_ni: 6.45e-7
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CFLAR
Novelty: 0.00108805
p_int: 0.999978129
p_ni: 0.000021731
p_wrong: 1.41e-7
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
Nearest Tclin Targets (3)
Upstream (3)
Pathways (117)
Reactome (38)
KEGG (31)
PathwayCommons (21)
WikiPathways (27)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation, myristolyation of BID and translocation to mitochondria | ||||
Reactome | Apoptosis | ||||
Reactome | Apoptotic cleavage of cellular proteins | ||||
Reactome | Apoptotic execution phase | ||||
Reactome | C-type lectin receptors (CLRs) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation, myristolyation of BID and translocation to mitochondria | ||||
Apoptosis | ||||
Apoptotic cleavage of cellular proteins | ||||
Apoptotic execution phase | ||||
C-type lectin receptors (CLRs) | ||||
Viral Interactions (0)
Gene Ontology Terms (64)
Functions (12)
Components (12)
Processes (40)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
5 | 5 | 1 | 1.1 | 97.8 | |||||
lymphocyte count | 3 | 3 | 3 | 95.8 | |||||
platelet crit | 2 | 2 | 2 | 89.1 | |||||
keratinocyte carcinoma | 1 | 1 | 0 | 1.1 | 83.8 | ||||
lymphocyte percentage of leukocytes | 2 | 2 | 2 | 83.6 | |||||
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
1 | 1.1 | 97.8 | |||||
lymphocyte count | 3 | 95.8 | |||||
platelet crit | 2 | 89.1 | |||||
keratinocyte carcinoma | 0 | 1.1 | 83.8 | ||||
lymphocyte percentage of leukocytes | 2 | 83.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | caspase 8 | VGNC:119 | 746477 | |||||
Macaque | caspase 8 | 702781 | ||||||
Mouse | MGI:1261423 | 12370 | ||||||
Rat | RGD:620945 | 64044 | ||||||
Dog | caspase 8 | VGNC:38736 | 488473 | |||||
Publication Statistics
PubMed Score 3840.67
PubMed score by year
PubTator Score 3511.69
PubTator score by year
Related Publications
Text Mined References (727)
GeneRif Annotations (519)
Items per page:
0 of 0
PMID | Year | Title |
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