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Tchem
CASP8
Caspase-8

Protein Summary
Description
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex. This gene encodes a member of the cysteine-aspartic acid prote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264274
  • ENSP00000264274
  • ENSG00000064012
  • ENST00000264275
  • ENSP00000264275
  • ENST00000323492
  • ENSP00000325722
  • ENST00000358485
  • ENSP00000351273
  • ENST00000392258
  • ENSP00000376087
  • ENST00000392263
  • ENSP00000376091
  • ENST00000432109
  • ENSP00000412523

Symbol
  • MCH5
  • CAP4
  • MACH
  • MCH5
  • FLICE
  • ALPS2B
  • Casp-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
hub protein
1
protein domain
0.97
protein complex
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
 GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3840.67   (req: < 5)
View Publications
Gene RIFs: 519   (req: <= 3)
View Gene RIFs
Antibodies: 1364   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3840.67   (req: >= 5)
Gene RIFs: 519   (req: > 3)
Antibodies: 1364   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 198
Explore Active Ligands
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basal cell carcinoma
EFO_0004193
5
5
1
1.1
97.8
lymphocyte count
EFO_0004587
3
3
3
95.8
platelet crit
EFO_0007985
2
2
2
89.1
keratinocyte carcinoma
EFO_0010176
1
1
0
1.1
83.8
lymphocyte percentage of leukocytes
EFO_0007993
2
2
2
83.6
Items per page:
1 – 5 of 28
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basal cell carcinoma
EFO_0004193
1
1.1
97.8
lymphocyte count
EFO_0004587
3
95.8
platelet crit
EFO_0007985
2
89.1
keratinocyte carcinoma
EFO_0010176
0
1.1
83.8
lymphocyte percentage of leukocytes
EFO_0007993
2
83.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caspase 8
VGNC:119
746477
Macaque
caspase 8
702781
Mouse
caspase 8
MGI:1261423
12370
Rat
caspase 8
RGD:620945
64044
Dog
caspase 8
VGNC:38736
488473
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caspase 8
Macaque
caspase 8
Mouse
caspase 8
Rat
caspase 8
Dog
caspase 8
Protein Structure (19 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14790-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 19
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (117)
Activation, myristolyation of BID and translocation to mitochondria (R-HSA-75108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 38
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation, myristolyation of BID and translocation to mitochondria
4 targets
R-HSA-75108
Reactome
Apoptosis
177 targets
R-HSA-109581
Reactome
Apoptotic cleavage of cellular proteins
38 targets
R-HSA-111465
Reactome
Apoptotic execution phase
52 targets
R-HSA-75153
Reactome
C-type lectin receptors (CLRs)
144 targets
R-HSA-5621481
Name
Explore in Pharos
Explore in Source
Activation, myristolyation of BID and translocation to mitochondria
4 targets
R-HSA-75108
Apoptosis
177 targets
R-HSA-109581
Apoptotic cleavage of cellular proteins
38 targets
R-HSA-111465
Apoptotic execution phase
52 targets
R-HSA-75153
C-type lectin receptors (CLRs)
144 targets
R-HSA-5621481
Gene Ontology Terms (64)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
cysteine-type endopeptidase activity
Inferred from Direct Assay (IDA)
UniProtKB
peptidase activity
Inferred from Direct Assay (IDA)
BHF-UCL
death effector domain binding
Inferred from Physical Interaction (IPI)
UniProtKB
identical protein binding
Inferred from Physical Interaction (IPI)
IntAct
scaffold protein binding
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
ubiquitin protein ligase binding
Inferred from Physical Interaction (IPI)
UniProtKB
cysteine-type endopeptidase activity involved in apoptotic process
Inferred from Mutant Phenotype (IMP)
UniProtKB
cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Inferred from Mutant Phenotype (IMP)
UniProtKB
cysteine-type peptidase activity
Traceable Author Statement (TAS)
ProtInc
death receptor binding
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (418)
1 – 10 of 418
FAS
Tbio
Novelty:  0.00043286
p_int:  0.999999548
p_ni:  4.5e-7
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
TNFRSF10A
Tchem
Novelty:  0.0003383
p_int:  0.999999361
p_ni:  6.25e-7
p_wrong:  1.4e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
TNFRSF10B
Tbio
Novelty:  0.00054433
p_int:  0.999999353
p_ni:  6.45e-7
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CFLAR
Tbio
Novelty:  0.00108805
p_int:  0.999978129
p_ni:  0.000021731
p_wrong:  1.41e-7
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
CASP7
Tchem
Family:  Enzyme
Novelty:  0.00126224
Score:  0.999
Data Source:  STRINGDB
CASP6
Tchem
Family:  Enzyme
Novelty:  0.00234346
Score:  0.999
Data Source:  STRINGDB
BCL2L1
Tchem
Novelty:  0.00018414
Score:  0.999
Data Source:  STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.999
Data Source:  STRINGDB
FADD
Tbio
Novelty:  0.00137968
Score:  0.999
Data Source:  Reactome,STRINGDB
XIAP
Tchem
Family:  Enzyme
Novelty:  0.00062268
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3840.67

PubMed score by year
PubTator Score  3511.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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