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Tchem
CBX2
Chromobox protein homolog 2

Protein Summary
Description
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780). This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269399
  • ENSP00000269399
  • ENSG00000173894
  • ENST00000310942
  • ENSP00000308750

Symbol
  • M33
  • CDCA6
  • SRXY5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
microRNA
0.78
protein domain
0.73
transcription factor binding site profile
0.71
transcription factor
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.23   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.23   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3780251
chemical structure image
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (23)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (168)
1 – 10 of 168
PCGF2
Tbio
Novelty: 0.02620321
p_int: 0.999999994
p_ni: 2e-9
p_wrong: 4e-9
Score: 0.991
Data Source: BioPlex,STRINGDB
PHC1
Tbio
Novelty: 0.02755105
p_int: 0.99999999
p_ni: 6e-9
p_wrong: 4e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
RPL7
Tbio
Novelty: 0.00758123
p_int: 0.999985243
p_ni: 0.000014757
Score: 0.21
Data Source: BioPlex,STRINGDB
PSME3
Tbio
Novelty: 0.01291641
p_int: 0.999943786
p_ni: 0.000056213
p_wrong: 1e-9
Score: 0.238
Data Source: BioPlex,STRINGDB
CSNK2B
Tbio
Family: Kinase
Novelty: 0.00171173
p_int: 0.999484679
p_ni: 0.000509703
p_wrong: 0.000005617
Data Source: BioPlex
L3MBTL1
Tchem
Family: TF; Epigenetic
Novelty: 0.00347268
p_int: 0.996972942
p_ni: 0.001899011
p_wrong: 0.001128046
Score: 0.392
Data Source: BioPlex,STRINGDB
PLCD4
Tbio
Family: Enzyme
Novelty: 0.06740018
p_int: 0.995319121
p_ni: 0.000448951
p_wrong: 0.004231928
Data Source: BioPlex
RING1
Tbio
Family: Enzyme
Novelty: 0.00497005
Score: 0.99
Data Source: STRINGDB
RNF2
Tbio
Family: Enzyme
Novelty: 0.0052742
Score: 0.989
Data Source: STRINGDB
PHC2
Tbio
Novelty: 0.00570052
Score: 0.977
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.23

PubMed score by year
PubTator Score  42.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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