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Tbio
HLX
H2.0-like homeobox protein

Protein Summary
Description
Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366903
  • ENSP00000355870
  • ENSG00000136630

Symbol
  • HLX1
  • HB24
  • HLX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
PubMedID
0.79
protein domain
0.73
transcription factor binding site profile
0.72
gene perturbation
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.42   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 234   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.42   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
96.9
C-reactive protein measurement
1
1
1
92.6
neutrophil count
2
2
2
80.9
eosinophil count
2
3
3
76.5
myeloid white cell count
1
1
1
73.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
96.9
C-reactive protein measurement
1
92.6
neutrophil count
2
80.9
eosinophil count
3
76.5
myeloid white cell count
1
73.3
Protein-Protein Interactions (43)
1 – 10 of 43
CEP120
Tbio
Novelty: 0.07215656
p_int: 0.999999998
p_ni: 2e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
TLE2
Tbio
Novelty: 0.03922169
p_int: 0.999897043
p_ni: 0.000102955
p_wrong: 1e-9
Score: 0.226
Data Source: BioPlex,STRINGDB
TLE4
Tbio
Novelty: 0.02094922
p_int: 0.999652562
p_ni: 0.000347438
Score: 0.572
Data Source: BioPlex,STRINGDB
C18orf25
Tdark
Novelty: 0.67505268
p_int: 0.999451469
p_ni: 0.000548531
Score: 0.217
Data Source: BioPlex,STRINGDB
TLE1
Tbio
Novelty: 0.00594261
p_int: 0.999450227
p_ni: 0.000549773
Score: 0.202
Data Source: BioPlex,STRINGDB
AES
Tbio
Novelty: 0.00818499
p_int: 0.999035328
p_ni: 0.000964668
p_wrong: 4e-9
Score: 0.753
Data Source: BioPlex,STRINGDB
CSNK2A1
Tchem
Family: Kinase
Novelty: 0.00187855
p_int: 0.993119026
p_ni: 0.006880974
Data Source: BioPlex
SEPHS1
Tbio
Family: Enzyme
Novelty: 0.01539662
p_int: 0.986423539
p_ni: 0.013576461
Score: 0.391
Data Source: BioPlex,STRINGDB
TLE3
Tbio
Novelty: 0.02641884
p_int: 0.977746096
p_ni: 0.022253872
p_wrong: 3.1e-8
Score: 0.182
Data Source: BioPlex,STRINGDB
CSNK2A2
Tchem
Family: Kinase
Novelty: 0.00231447
p_int: 0.940262233
p_ni: 0.059737767
Data Source: BioPlex
Publication Statistics
PubMed Score  106.42

PubMed score by year
PubTator Score  38.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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