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Tbio
ICAM4
Intercellular adhesion molecule 4

Protein Summary
Description
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins. This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340992
  • ENSP00000342114
  • ENSG00000105371
  • ENST00000380770
  • ENSP00000370147
  • ENST00000393717
  • ENSP00000377320

Symbol
  • LW
  • LW
  • CD242
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.66
tissue
0.59
transcription factor binding site profile
0.59
gene perturbation
0.54
disease
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.28   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.28   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (19)
1 – 10 of 19
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.999961634
p_ni:  0.000038238
p_wrong:  1.29e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
p_int:  0.999843933
p_ni:  0.000155872
p_wrong:  1.95e-7
Data Source:  BioPlex
HFE
Tbio
Novelty:  0.00042077
p_int:  0.997923903
p_ni:  0.001786191
p_wrong:  0.000289907
Data Source:  BioPlex
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.956
Data Source:  STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.946
Data Source:  STRINGDB
ITGAL
Tclin
Novelty:  0.00099016
Score:  0.945
Data Source:  STRINGDB
BCAM
Tbio
Novelty:  0.01697541
Score:  0.63
Data Source:  STRINGDB
RHAG
Tbio
Novelty:  0.00094983
Score:  0.619
Data Source:  STRINGDB
ITGA4
Tclin
Novelty:  0.00197607
Score:  0.558
Data Source:  STRINGDB
ICAM2
Tbio
Novelty:  0.00480584
Score:  0.555
Data Source:  STRINGDB
Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Extracellular matrix organization
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
Integrin cell surface interactions
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Extracellular matrix organization
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ICAM-1 measurement
2
3
0
13.8
97.6
IGF-1 measurement
1
4
4
96.7
reticulocyte count
7
7
13
95.2
6
5
0
1.2
92
myeloid white cell count
2
2
2
91.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ICAM-1 measurement
0
13.8
97.6
IGF-1 measurement
4
96.7
reticulocyte count
13
95.2
0
1.2
92
myeloid white cell count
2
91.5
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
intercellular adhesion molecule 4
VGNC:2352
455698
Macaque
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
712354
Mouse
MGI:1925619
78369
Rat
RGD:1308971
298702
Dog
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
611265
Species
Name
OMA
EggNOG
Inparanoid
Chimp
intercellular adhesion molecule 4
Macaque
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
Mouse
Rat
Dog
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
Publication Statistics
PubMed Score 34.28
PubMed score by year
PubTator Score 37.13
PubTator score by year