Tbio LTBP1 Latent-transforming growth factor beta-binding protein 1

Protein Summary

Description

Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q14766
• A1L3V1
• P22064
• Q53SD8
• Q53SF3
• Q53SG1
• Q59HF7
• Q8TD95
• LTBP-1

Gene Name

• LTBP1

Ensembl ID

• ENST00000404525
• ENSP00000385359
• ENSG00000049323
• ENST00000404816
• ENSP00000386043
• ENST00000407925
• ENSP00000384091

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.99
protein domain	0.92
transcription factor	0.88
transcription factor perturbation	0.88
molecular function	0.86

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Latent-transforming Growth Factor Beta-binding Protein 1

Protein / Extracellular Matrix Protein / Extracellular Matrix Structural Protein / Latent-transforming Growth Factor Beta-binding Protein 1

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Latent-transforming Growth Factor Beta-binding Protein 1

Protein / Cell Adhesion Molecule / Latent-transforming Growth Factor Beta-binding Protein 1

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Latent-transforming Growth Factor Beta-binding Protein 1

Protein / Calcium-binding Protein / Annexin / Latent-transforming Growth Factor Beta-binding Protein 1

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Latent-transforming Growth Factor Beta-binding Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.72   (req: < 5)

Gene RIFs: 70   (req: <= 3)

Antibodies: 193   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.72   (req: >= 5)

Gene RIFs: 70   (req: > 3)

Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0