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Tbio
STAT4
Signal transducer and activator of transcription 4

Protein Summary
Description
Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358470
  • ENSP00000351255
  • ENSG00000138378
  • ENST00000392320
  • ENSP00000376134

Symbol
  • SLEB11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
0.99
PubMedID
0.94
disease
0.9
gene perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 387.14   (req: < 5)
Gene RIFs: 177   (req: <= 3)
Antibodies: 1034   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 387.14   (req: >= 5)
Gene RIFs: 177   (req: > 3)
Antibodies: 1034   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
16
10
0
1.5
99.8
7
6
1
1.3
99.3
5
4
3
1.2
96
1
2
0
1.3
92.8
3
4
0
1.4
92.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
99.8
1
1.3
99.3
3
1.2
96
0
1.3
92.8
0
1.4
92.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
signal transducer and activator of transcription 4
693854
Mouse
MGI:103062
20849
Rat
Horse
signal transducer and activator of transcription 4
VGNC:23666
100054693
Pig
signal transducer and activator of transcription 4
397261
Species
Name
OMA
EggNOG
Inparanoid
Macaque
signal transducer and activator of transcription 4
Mouse
Rat
Horse
signal transducer and activator of transcription 4
Pig
signal transducer and activator of transcription 4
Pathways (99)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Reactome
Immune System
Reactome
Interleukin-12 family signaling
Reactome
Interleukin-12 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Immune System
Interleukin-12 family signaling
Interleukin-12 signaling
Protein-Protein Interactions (245)
1 – 10 of 245
STAT1
Tchem
Family: TF
Novelty: 0.0003383
p_int: 0.988009607
p_ni: 0.011990393
Score: 0.945
Data Source: BioPlex,Reactome,STRINGDB
ZNF136
Tdark
Family: TF
Novelty: 0.68698067
p_int: 0.871728249
p_ni: 0.10417591
p_wrong: 0.024095841
Data Source: BioPlex
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.984
Data Source: Reactome,STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.983
Data Source: Reactome,STRINGDB
IL12RB1
Tbio
Novelty: 0.00398741
Score: 0.98
Data Source: Reactome,STRINGDB
TYK2
Tclin
Family: Kinase
Novelty: 0.00237955
Score: 0.978
Data Source: Reactome,STRINGDB
IL12RB2
Tbio
Novelty: 0.02023198
Score: 0.978
Data Source: Reactome,STRINGDB
IL10
Tbio
Novelty: 0.00004352
Score: 0.978
Data Source: STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
Score: 0.975
Data Source: STRINGDB
JAK3
Tclin
Family: Kinase
Novelty: 0.00164278
Score: 0.975
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  387.14

PubMed score by year
PubTator Score  347.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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