You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MVP
Major vault protein

Protein Summary
Description
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357402
  • ENSP00000349977
  • ENSG00000013364
  • ENST00000395353
  • ENSP00000378760

Symbol
  • LRP
  • LRP
  • VAULT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
interacting protein
0.92
disease perturbation
0.9
gene perturbation
0.88
small molecule perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.46   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 668   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.46   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 668   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
PARP4
Tchem
Family:  Enzyme
Novelty:  0.02135745
p_int:  0.999991674
p_ni:  2.25e-7
p_wrong:  0.0000081
Score:  0.965
Data Source:  BioPlex,STRINGDB
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.99996631
p_ni:  0.000033623
p_wrong:  6.7e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
GOPC
Tbio
Novelty:  0.01110168
p_int:  0.979842034
p_ni:  0.020157966
Data Source:  BioPlex
RCOR3
Tdark
Family:  TF
Novelty:  0.18886215
p_int:  0.885807595
p_ni:  0.114192405
Score:  0.189
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.766236042
p_ni:  0.233763958
Score:  0.272
Data Source:  BioPlex,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
TEP1
Tbio
Family:  Enzyme
Novelty:  0.01254647
Score:  0.897
Data Source:  STRINGDB
PARP9
Tbio
Family:  Enzyme
Novelty:  0.02702134
Score:  0.703
Data Source:  STRINGDB
C19orf48
Tdark
Novelty:  0.00628139
Score:  0.669
Data Source:  STRINGDB
VWF
Tclin
Novelty:  0.00009007
Score:  0.641
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
82
visceral adipose tissue measurement
1
1
1
77.4
waist-hip ratio
1
1
1
73.2
mean platelet volume
3
2
3
72.9
2
1
2
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
82
visceral adipose tissue measurement
1
77.4
waist-hip ratio
1
73.2
mean platelet volume
3
72.9
2
66.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
major vault protein
VGNC:13741
454027
Mouse
MGI:1925638
78388
Rat
RGD:70932
64681
Dog
major vault protein
VGNC:43510
479783
Horse
major vault protein
VGNC:20453
100063984
Species
Name
OMA
EggNOG
Inparanoid
Chimp
major vault protein
Mouse
Rat
Dog
major vault protein
Horse
major vault protein
Publication Statistics
PubMed Score 233.46
PubMed score by year
PubTator Score 225.14
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title