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Tbio
LBR
Lamin-B receptor

Protein Summary
Description
Anchors the lamina and the heterochromatin to the inner nuclear membrane. The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272163
  • ENSP00000272163
  • ENSG00000143815
  • ENST00000338179
  • ENSP00000339883

Symbol
  • PHA
  • C14SR
  • LMN2R
  • PHASK
  • TDRD18
  • DHCR14B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.95
transcription factor binding site profile
0.88
interacting protein
0.84
microRNA
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 509.34   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 509.34   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (138)
MAD2L1BP
Tbio
Novelty:  0.48374717
p_int:  0.999781285
p_ni:  0.000122666
p_wrong:  0.00009605
Score:  0.239
Data Source:  BioPlex,STRINGDB
ZNF579
Tdark
Family:  TF
Novelty:  4.75515836
p_int:  0.998281653
p_ni:  0.001718344
p_wrong:  3e-9
Score:  0.683
Data Source:  BioPlex,STRINGDB
DDX54
Tbio
Family:  Enzyme
Novelty:  0.12769464
p_int:  0.992888346
p_ni:  0.007111654
Data Source:  BioPlex
CHTOP
Tbio
Novelty:  0.04170391
p_int:  0.956181673
p_ni:  0.043818327
Score:  0.214
Data Source:  BioPlex,STRINGDB
LUC7L
Tbio
Novelty:  0.05748021
p_int:  0.937444876
p_ni:  0.062555124
Score:  0.163
Data Source:  BioPlex,STRINGDB
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.910956705
p_ni:  0.089043295
Data Source:  BioPlex
BHLHA15
Tbio
Family:  TF
Novelty:  0.02721846
p_int:  0.861118555
p_ni:  0.138881445
Score:  0.263
Data Source:  BioPlex,STRINGDB
CLEC3A
Tdark
Novelty:  0.21498836
p_int:  0.824975215
p_ni:  0.175024785
Score:  0.264
Data Source:  BioPlex,STRINGDB
ZNF385C
Tdark
Novelty:  2.23931637
p_int:  0.764299262
p_ni:  0.235700738
Data Source:  BioPlex
CYP51A1
Tchem
Family:  Enzyme
Novelty:  0.00127373
Score:  0.981
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (45)
Cholesterol biosynthesis (R-HSA-191273)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cholesterol biosynthesis
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Cholesterol biosynthesis
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
62.8
feeling nervous measurement
1
1
0
5.9
31.4
body height
1
1
1
17.8
mean corpuscular volume
1
1
1
9.5
mathematical ability
1
1
1
3.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
62.8
feeling nervous measurement
0
5.9
31.4
body height
1
17.8
mean corpuscular volume
1
9.5
mathematical ability
1
3.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lamin B receptor
VGNC:1293
457776
Macaque
lamin B receptor
700801
Mouse
MGI:2138281
98386
Dog
lamin B receptor
VGNC:42602
490391
Horse
lamin B receptor
VGNC:19601
100056997
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lamin B receptor
Macaque
lamin B receptor
Mouse
Dog
lamin B receptor
Horse
lamin B receptor
Publication Statistics
PubMed Score 509.34
PubMed score by year
PubTator Score 362.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title