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Tbio
PPP2R5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

Protein Summary
Description
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394110
  • ENSP00000377669
  • ENSG00000112640
  • ENST00000461010
  • ENSP00000420674
  • ENST00000485511
  • ENSP00000417963

Symbol
  • B56D
  • MRD35
  • B56delta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.8
pathway
0.75
drug perturbation
0.71
biological process
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.81   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.81   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (372)
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
p_int:  0.999999972
p_ni:  2.7e-8
p_wrong:  1e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
p_int:  0.999999944
p_ni:  5.6e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
PRR14
Tbio
Novelty:  0.22401806
p_int:  0.99999923
p_ni:  7.43e-7
p_wrong:  2.7e-8
Score:  0.186
Data Source:  BioPlex,STRINGDB
CCNG2
Tbio
Novelty:  0.01824057
p_int:  0.99985221
p_ni:  0.000147752
p_wrong:  3.8e-8
Score:  0.441
Data Source:  BioPlex,STRINGDB
FAM43A
Tdark
Novelty:  1.17401589
p_int:  0.999127678
p_ni:  0.000863771
p_wrong:  0.000008552
Score:  0.177
Data Source:  BioPlex,STRINGDB
WNT3A
Tchem
Novelty:  0.00119275
p_int:  0.9990866
p_ni:  0.0009134
Score:  0.912
Data Source:  BioPlex,STRINGDB
CCNG1
Tbio
Novelty:  0.00838635
p_int:  0.994294237
p_ni:  0.005705762
Score:  0.388
Data Source:  BioPlex,STRINGDB
PPME1
Tchem
Family:  Enzyme
Novelty:  0.01559862
p_int:  0.968143968
p_ni:  0.031856032
Score:  0.767
Data Source:  BioPlex,STRINGDB
CELA3A
Tbio
Family:  Enzyme
Novelty:  0.04100319
p_int:  0.952749045
p_ni:  0.047214775
p_wrong:  0.00003618
Data Source:  BioPlex
BCAT1
Tchem
Family:  Enzyme
Novelty:  0.00616446
p_int:  0.927085523
p_ni:  0.07289786
p_wrong:  0.000016618
Score:  0.157
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
1 – 5 of 7
CACNA1C
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  2
CACNA1D
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  2
CACNA2D1
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
RYR2
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
Pathways (121)
AMER1 mutants destabilize the destruction complex (R-HSA-4839748)

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Items per page:
1 – 5 of 94
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMER1 mutants destabilize the destruction complex
Reactome
APC truncation mutants have impaired AXIN binding
Reactome
AXIN missense mutants destabilize the destruction complex
Reactome
AXIN mutants destabilize the destruction complex, activating WNT signaling
Reactome
Adaptive Immune System
Name
Explore in Pharos
Explore in Source
AMER1 mutants destabilize the destruction complex
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
Adaptive Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
3
3
92.7
apolipoprotein B measurement
2
3
3
86.8
high density lipoprotein cholesterol measurement
3
3
4
83.6
bilirubin measurement
1
1
1
67.3
homocysteine measurement
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
3
92.7
apolipoprotein B measurement
3
86.8
high density lipoprotein cholesterol measurement
4
83.6
bilirubin measurement
1
67.3
homocysteine measurement
1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 regulatory subunit B'delta
VGNC:13034
462705
Macaque
protein phosphatase 2 regulatory subunit B'delta
699163
Mouse
MGI:2388481
21770
Rat
RGD:1306666
363193
Dog
protein phosphatase 2 regulatory subunit B'delta
VGNC:44916
481806
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 regulatory subunit B'delta
Macaque
protein phosphatase 2 regulatory subunit B'delta
Mouse
Rat
Dog
protein phosphatase 2 regulatory subunit B'delta
Publication Statistics
PubMed Score 24.81
PubMed score by year
PubTator Score 5.72
PubTator score by year
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Related Publications
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PMID
Year
Title