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Tbio
MFSD10
Major facilitator superfamily domain-containing protein 10

Protein Summary
Description
Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump. This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329687
  • ENSP00000332646
  • ENSG00000109736
  • ENST00000355443
  • ENSP00000347619

Symbol
  • TETRAN
  • TETRAN
  • TETTRAN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
kinase perturbation
0.76
tissue sample
0.72
transcription factor binding site profile
0.71
transcription factor
0.69


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.67   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.67   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
major facilitator superfamily domain containing 10
VGNC:635
461081
Macaque
major facilitator superfamily domain containing 10
720098
Mouse
MGI:1915544
68294
Rat
RGD:1311900
305449
Dog
major facilitator superfamily domain containing 10
VGNC:43196
488795
Species
Name
OMA
EggNOG
Inparanoid
Chimp
major facilitator superfamily domain containing 10
Macaque
major facilitator superfamily domain containing 10
Mouse
Rat
Dog
major facilitator superfamily domain containing 10
Protein-Protein Interactions (67)
1 – 10 of 67
TMEM63A
Tdark
Family: IC
Novelty: 0.33131011
p_int: 0.999999318
p_ni: 4.75e-7
p_wrong: 2.06e-7
Score: 0.205
Data Source: BioPlex,STRINGDB
SERINC5
Tbio
Novelty: 0.01787232
Score: 0.937
Data Source: STRINGDB
CHIT1
Tbio
Family: Enzyme
Novelty: 0.00113383
Score: 0.807
Data Source: STRINGDB
MFSD5
Tdark
Novelty: 0.58146966
Score: 0.801
Data Source: STRINGDB
MFSD4B
Tdark
Novelty: 0.03380333
Score: 0.774
Data Source: STRINGDB
MFSD11
Tdark
Novelty: 0.13167358
Score: 0.77
Data Source: STRINGDB
SVOP
Tbio
Novelty: 0.0830639
Score: 0.766
Data Source: STRINGDB
SVOPL
Tdark
Novelty: 0.46448049
Score: 0.766
Data Source: STRINGDB
MFSD8
Tbio
Novelty: 0.03388459
Score: 0.737
Data Source: STRINGDB
PAPOLB
Tbio
Family: Enzyme
Novelty: 0.05769194
Score: 0.732
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.67

PubMed score by year
PubTator Score  1.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer