Tbio MFSD10 Major facilitator superfamily domain-containing protein 10

Protein Summary

Description

Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump. This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q14728
• Q07706

Gene Name

• MFSD10

Ensembl ID

• ENST00000329687
• ENSP00000332646
• ENSG00000109736
• ENST00000355443
• ENSP00000347619

Symbol

• TETRAN
• TETRAN
• TETTRAN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.83
kinase perturbation	0.76
tissue sample	0.72
transcription factor binding site profile	0.71
transcription factor	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.69   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 75   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.69   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0