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Tclin
KCNB1
Potassium voltage-gated channel subfamily B member 1

Protein Summary
Description
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:23161216). Plays also a role in the regulation of exocytosis independently of its electrical function (By similarity). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolariz ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371741
  • ENSP00000360806
  • ENSG00000158445
  • ENST00000635465
  • ENSP00000489193

Symbol
  • DRK1
  • Kv2.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.88
transcription factor binding site profile
0.75
transcription factor
0.72
kinase perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 555.58   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 555.58   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
4
1
5.7
87
mathematical ability
2
1
2
79
unipolar depression
1
2
0
5.9
76.3
wellbeing measurement
3
1
3
68.9
neuroticism measurement
1
1
1
58.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
5.7
87
mathematical ability
2
79
unipolar depression
0
5.9
76.3
wellbeing measurement
3
68.9
neuroticism measurement
1
58.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily B member 1
VGNC:14250
469965
Macaque
potassium voltage-gated channel subfamily B member 1
703520
Mouse
MGI:96666
16500
Rat
RGD:2954
25736
Dog
potassium voltage-gated channel subfamily B member 1
VGNC:42235
485918
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily B member 1
Macaque
potassium voltage-gated channel subfamily B member 1
Mouse
Rat
Dog
potassium voltage-gated channel subfamily B member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14721-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (R-HSA-381676)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Reactome
Integration of energy metabolism
Reactome
Metabolism
Reactome
Neuronal System
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Integration of energy metabolism
Metabolism
Neuronal System
Potassium Channels
Gene Ontology Terms (35)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (181)
1 – 10 of 181
KCNAB1
Tbio
Family: IC
Novelty: 0.01413705
Score: 0.972
Data Source: STRINGDB
KCNAB2
Tbio
Family: IC
Novelty: 0.01752175
Score: 0.964
Data Source: STRINGDB
KCNAB3
Tbio
Family: IC
Novelty: 0.10128237
Score: 0.947
Data Source: STRINGDB
AKAP5
Tbio
Family: Enzyme
Novelty: 0.00351101
Score: 0.932
Data Source: STRINGDB
PRKACB
Tchem
Family: Kinase
Novelty: 0.01962222
Score: 0.902
Data Source: STRINGDB
PRKAR2B
Tbio
Family: Enzyme
Novelty: 0.00456972
Score: 0.902
Data Source: STRINGDB
PRKAR2A
Tbio
Family: Enzyme
Novelty: 0.06183318
Score: 0.902
Data Source: STRINGDB
IQGAP1
Tbio
Family: Enzyme
Novelty: 0.00434481
Score: 0.902
Data Source: STRINGDB
PRKACG
Tbio
Family: Kinase
Novelty: 0.11080061
Score: 0.902
Data Source: STRINGDB
PRKAR1B
Tbio
Family: Enzyme
Novelty: 0.05355517
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  555.58

PubMed score by year
PubTator Score  235.62

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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