You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
MBTPS1
Membrane-bound transcription factor site-1 protease

Protein Summary
Description
Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes. This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343411
  • ENSP00000344223
  • ENSG00000140943

Symbol
  • KIAA0091
  • S1P
  • SKI1
  • S1P
  • PCSK8
  • SKI-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
virus perturbation
0.92
kinase perturbation
0.91
cellular component
0.9
histone modification site profile
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.89   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.89   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (173)
1 – 10 of 173
PAGE1
Tbio
Novelty:  0.02731969
p_int:  0.977215234
p_ni:  0.022784766
Data Source:  BioPlex
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.969218861
p_ni:  0.030781139
Score:  0.573
Data Source:  BioPlex,STRINGDB
PCBP3
Tbio
Novelty:  0.11681812
p_int:  0.966804356
p_ni:  0.031188919
p_wrong:  0.002006725
Data Source:  BioPlex
BTNL3
Tdark
Novelty:  0.27343899
p_int:  0.941759158
p_ni:  0.058240842
Data Source:  BioPlex
SP3
Tbio
Family:  TF
Novelty:  0.00119924
p_int:  0.862285858
p_ni:  0.137681606
p_wrong:  0.000032535
Data Source:  BioPlex
CANX
Tbio
Novelty:  0.00087002
p_int:  0.858655061
p_ni:  0.141344939
Score:  0.631
Data Source:  BioPlex,STRINGDB
TAZ
Tbio
Novelty:  0.00372301
p_int:  0.856718361
p_ni:  0.143281639
Score:  0.512
Data Source:  BioPlex,STRINGDB
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
p_int:  0.791241811
p_ni:  0.208758162
p_wrong:  2.8e-8
Score:  0.343
Data Source:  BioPlex,STRINGDB
SIAE
Tbio
Family:  Enzyme
Novelty:  0.01138067
p_int:  0.789406948
p_ni:  0.210593049
p_wrong:  3e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
ATF6
Tbio
Family:  TF
Novelty:  0.00149266
Score:  0.982
Data Source:  Reactome,STRINGDB
Pathways (17)
ATF6 (ATF6-alpha) activates chaperones (R-HSA-381033)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF6 (ATF6-alpha) activates chaperones
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
CREB3 factors activate genes
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
ATF6 (ATF6-alpha) activates chaperones
Assembly of active LPL and LIPC lipase complexes
CREB3 factors activate genes
Metabolism
Metabolism of lipids
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adiponectin measurement
1
1
1
62.6
alkaline phosphatase measurement
1
1
1
50.6
mathematical ability
1
1
1
35
IGF-1 measurement
1
1
1
33.1
self reported educational attainment
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adiponectin measurement
1
62.6
alkaline phosphatase measurement
1
50.6
mathematical ability
1
35
IGF-1 measurement
1
33.1
self reported educational attainment
1
15.8
Find similar targets by:
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
membrane bound transcription factor peptidase, site 1
VGNC:9087
468050
Macaque
membrane bound transcription factor peptidase, site 1
714706
Mouse
MGI:1927235
56453
Rat
RGD:70935
89842
Dog
membrane bound transcription factor peptidase, site 1
VGNC:43064
489684
Species
Name
OMA
EggNOG
Inparanoid
Chimp
membrane bound transcription factor peptidase, site 1
Macaque
membrane bound transcription factor peptidase, site 1
Mouse
Rat
Dog
membrane bound transcription factor peptidase, site 1
Publication Statistics
PubMed Score 129.89
PubMed score by year
PubTator Score 171.43
PubTator score by year