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Tchem
USP10
Ubiquitin carboxyl-terminal hydrolase 10

Protein Summary
Description
Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219473
  • ENSP00000219473
  • ENSG00000103194
  • ENST00000570191
  • ENSP00000457411

Symbol
  • KIAA0190
  • UBPO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.88
disease perturbation
0.87
kinase perturbation
0.84
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.77   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 328   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.77   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL2391504
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
4
7
68.8
reticulocyte measurement
3
3
4
63.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
68.8
reticulocyte measurement
4
63.6
Pathways (8)
DNA Damage Bypass (R-HSA-73893)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Bypass
Reactome
DNA Repair
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
DNA Damage Bypass
DNA Repair
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (21)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (145)
1 – 10 of 145
ANKRD44
Tdark
Family: Enzyme
Novelty: 0.38360979
p_int: 0.99999946
p_ni: 5.19e-7
p_wrong: 2e-8
Score: 0.705
Data Source: BioPlex,STRINGDB
G3BP2
Tbio
Family: Enzyme
Novelty: 0.04786241
p_int: 0.999984529
p_ni: 0.000015471
Score: 0.983
Data Source: BioPlex,STRINGDB
ANKRD52
Tbio
Family: Enzyme
Novelty: 0.14147652
p_int: 0.999817422
p_ni: 0.000182578
Score: 0.405
Data Source: BioPlex,STRINGDB
AARSD1
Tdark
Novelty: 0.75372406
p_int: 0.999520985
p_ni: 0.000479015
Data Source: BioPlex
ANKRD28
Tbio
Family: Enzyme
Novelty: 0.10895759
p_int: 0.999194837
p_ni: 0.000805163
Score: 0.563
Data Source: BioPlex,STRINGDB
PPP4R3A
Tbio
Family: Enzyme
Novelty: 0.04234592
p_int: 0.99831525
p_ni: 0.001684747
p_wrong: 3e-9
Score: 0.421
Data Source: BioPlex,STRINGDB
GFAP
Tbio
Novelty: 0.00020932
p_int: 0.995621763
p_ni: 0.004378191
p_wrong: 4.6e-8
Data Source: BioPlex
PPP6R2
Tbio
Family: Enzyme
Novelty: 0.12886225
p_int: 0.989330719
p_ni: 0.010669281
Score: 0.685
Data Source: BioPlex,STRINGDB
KLHDC3
Tdark
Novelty: 0.63840156
p_int: 0.987751195
p_ni: 0.012248805
Score: 0.196
Data Source: BioPlex,STRINGDB
G3BP1
Tbio
Family: Enzyme
Novelty: 0.00589987
p_int: 0.964204913
p_ni: 0.035795087
Score: 0.996
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  22.77

PubMed score by year
PubTator Score  27.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer