Tbio LPIN1 Phosphatidate phosphatase LPIN1

Protein Summary

Description

Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity). This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. [provided by RefSeq, Mar 2017]

Uniprot Accession IDs

• Q14693
• A8MU38
• B4DET9
• B4DGS4
• B4DGZ6
• B5MC18
• B7Z858
• D6W506
• E7ESE7
• F5GY24
• Q53T25

Gene Name

• LPIN1

Ensembl ID

• ENST00000256720
• ENSP00000256720
• ENSG00000134324
• ENST00000396097
• ENSP00000379404
• ENST00000396098
• ENSP00000379405
• ENST00000425416
• ENSP00000401522
• ENST00000449576
• ENSP00000397908

Symbol

• KIAA0188
• PAP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
biological process	0.99
kinase perturbation	0.99
transcription factor binding site profile	0.91
transcription factor perturbation	0.91

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.42   (req: < 5)

Gene RIFs: 84   (req: <= 3)

Antibodies: 387   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.42   (req: >= 5)

Gene RIFs: 84   (req: > 3)

Antibodies: 387   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0