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Tbio
LPIN1
Phosphatidate phosphatase LPIN1

Protein Summary
Description
Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity). This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some perox ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256720
  • ENSP00000256720
  • ENSG00000134324
  • ENST00000396097
  • ENSP00000379404
  • ENST00000396098
  • ENSP00000379405
  • ENST00000425416
  • ENSP00000401522
  • ENST00000449576
  • ENSP00000397908

Symbol
  • KIAA0188
  • PAP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
biological process
0.99
kinase perturbation
0.99
transcription factor binding site profile
0.91
transcription factor perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.1   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 387   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.1   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 387   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (175)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Depolymerisation of the Nuclear Lamina
Reactome
Glycerophospholipid biosynthesis
Reactome
M Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Depolymerisation of the Nuclear Lamina
Glycerophospholipid biosynthesis
M Phase
Protein-Protein Interactions (123)
1 – 10 of 123
LPIN3
Tbio
Family: Enzyme
Novelty: 0.01641336
p_int: 0.999999994
p_wrong: 6e-9
Score: 0.955
Data Source: BioPlex,STRINGDB
CTDNEP1
Tbio
Family: Enzyme
Novelty: 0.09348082
Score: 0.989
Data Source: Reactome,STRINGDB
CNEP1R1
Tbio
Family: Enzyme
Novelty: 0.68482554
Score: 0.955
Data Source: STRINGDB
LPL
Tchem
Family: Enzyme
Novelty: 0.00057058
Score: 0.942
Data Source: STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.931
Data Source: Reactome,STRINGDB
DGAT1
Tclin
Family: Enzyme
Novelty: 0.00121009
Score: 0.929
Data Source: STRINGDB
PRKCB
Tchem
Family: Kinase
Novelty: 0.00189802
Score: 0.914
Data Source: STRINGDB
PRKCA
Tchem
Family: Kinase
Novelty: 0.00057611
Score: 0.914
Data Source: STRINGDB
LPIN2
Tbio
Family: Enzyme
Novelty: 0.01901948
Score: 0.907
Data Source: STRINGDB
AGPAT2
Tchem
Family: Enzyme
Novelty: 0.01321334
Score: 0.903
Data Source: STRINGDB
Publication Statistics
PubMed Score  225.10

PubMed score by year
PubTator Score  113.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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