Tbio PDCD11 Protein RRP5 homolog

Protein Summary

Description

Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. Involved in the biogenesis of rRNA. PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed 17654514]).[supplied by OMIM, Oct 2008]

Uniprot Accession IDs

• Q14690
• Q2TA92
• Q5W093
• Q6P2J3
• Q86VQ8
• Q9H4P1

Gene Name

• PDCD11

Ensembl ID

• ENST00000369797
• ENSP00000358812
• ENSG00000148843

Symbol

• KIAA0185
• ALG4
• NFBP
• RRP5
• ALG-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.99
protein domain	0.92
histone modification site profile	0.9
transcription factor binding site profile	0.81
disease perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Protein Rrp5 Homolog

DTO Classes

Protein / Nucleic Acid Binding / Protein Rrp5 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.82   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 38   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.82   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0