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Tbio
RRP1B
Ribosomal RNA processing protein 1 homolog B

Protein Summary
Description
Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340648
  • ENSP00000339145
  • ENSG00000160208

Symbol
  • KIAA0179
  • Nnp1
  • RRP1
  • NNP1L
  • KIAA0179
  • PPP1R136
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.99
kinase perturbation
0.96
transcription factor perturbation
0.96
interacting protein
0.9
disease perturbation
0.87


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.34   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.34   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal RNA processing 1B
VGNC:1127
474031
Macaque
ribosomal RNA processing 1B
713759
Mouse
MGI:1919712
72462
Rat
RGD:1305633
309673
Dog
ribosomal RNA processing 1B
VGNC:45766
478423
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal RNA processing 1B
Macaque
ribosomal RNA processing 1B
Mouse
Rat
Dog
ribosomal RNA processing 1B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14684-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (22)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (267)
1 – 10 of 267
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00465946
p_int: 0.965649443
p_ni: 0.034350557
Score: 0.289
Data Source: BioPlex,STRINGDB
MAGEB10
Tdark
Novelty: 2.96156972
p_int: 0.930209227
p_ni: 0.069790773
Score: 0.199
Data Source: BioPlex,STRINGDB
RRP8
Tbio
Family: Enzyme
Novelty: 0.04922797
p_int: 0.878492162
p_ni: 0.121507834
p_wrong: 3e-9
Score: 0.774
Data Source: BioPlex,STRINGDB
HEATR3
Tbio
Novelty: 0.08367436
p_int: 0.876786014
p_ni: 0.123213986
Data Source: BioPlex
MECP2
Tchem
Family: TF
Novelty: 0.00051767
p_int: 0.858986779
p_ni: 0.141013221
Data Source: BioPlex
DGKZ
Tbio
Family: Enzyme
Novelty: 0.01312044
p_int: 0.79901686
p_ni: 0.20098314
Data Source: BioPlex
RPS13
Tbio
Novelty: 0.0019983
p_int: 0.78391611
p_ni: 0.21608389
Score: 0.263
Data Source: BioPlex,STRINGDB
RPL7L1
Tdark
Novelty: 0.78428937
p_int: 0.756518867
p_ni: 0.243481133
Score: 0.509
Data Source: BioPlex,STRINGDB
SART3
Tbio
Novelty: 0.02353492
p_int: 0.753438528
p_ni: 0.246561472
Score: 0.156
Data Source: BioPlex,STRINGDB
RPL18A
Tbio
Novelty: 0.04612948
p_int: 0.75186319
p_ni: 0.24813681
Score: 0.534
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  14.34

PubMed score by year
PubTator Score  8.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer