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Tbio
SMC1A
Structural maintenance of chromosomes protein 1A

Protein Summary
Description
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322213
  • ENSP00000323421
  • ENSG00000072501

Symbol
  • DXS423E
  • KIAA0178
  • SB1.8
  • SMC1
  • SMC1L1
  • SMC1
  • SMCB
  • CDLS2
  • SB1.8
  • SMC1L1
  • DXS423E
  • SMC1alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
molecular function
0.99
protein complex
0.97
hub protein
0.94
histone modification site profile
0.82


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.18   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 858   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.18   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 858   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
structural maintenance of chromosomes 1A
VGNC:11642
473619
Macaque
structural maintenance of chromosomes 1A
677711
Mouse
MGI:1344345
24061
Rat
RGD:61991
63996
Dog
structural maintenance of chromosomes 1A
VGNC:46541
480928
Species
Name
OMA
EggNOG
Inparanoid
Chimp
structural maintenance of chromosomes 1A
Macaque
structural maintenance of chromosomes 1A
Mouse
Rat
Dog
structural maintenance of chromosomes 1A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14683-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (41)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cohesin Loading onto Chromatin
Reactome
ESR-mediated signaling
Reactome
Establishment of Sister Chromatid Cohesion
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cohesin Loading onto Chromatin
ESR-mediated signaling
Establishment of Sister Chromatid Cohesion
Gene Ontology Terms (28)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (341)
1 – 10 of 341
RAD21
Tbio
Novelty: 0.00270936
p_int: 0.999720386
p_ni: 0.000279614
Score: 0.999
Data Source: BioPlex,STRINGDB
REC8
Tbio
Novelty: 0.00732742
p_int: 0.999143923
p_ni: 0.000856077
Score: 0.983
Data Source: BioPlex,STRINGDB
PSMC2
Tbio
Family: Enzyme
Novelty: 0.08240664
p_int: 0.83313713
p_ni: 0.16686287
Score: 0.845
Data Source: BioPlex,STRINGDB
PDS5A
Tbio
Novelty: 0.0142948
Score: 0.999
Data Source: STRINGDB
SMC3
Tbio
Novelty: 0.00474377
Score: 0.999
Data Source: STRINGDB
PDS5B
Tbio
Novelty: 0.00295057
Score: 0.999
Data Source: STRINGDB
STAG2
Tbio
Novelty: 0.00430441
Score: 0.999
Data Source: STRINGDB
STAG1
Tbio
Novelty: 0.00122511
Score: 0.998
Data Source: STRINGDB
NIPBL
Tbio
Novelty: 0.00462654
Score: 0.997
Data Source: STRINGDB
WAPL
Tbio
Novelty: 0.01598061
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  109.18

PubMed score by year
PubTator Score  142.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer