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Tdark
KCTD2
BTB/POZ domain-containing protein KCTD2

Protein Classes
Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322444
  • ENSP00000312814
  • ENSG00000180901

Symbol
  • KIAA0176
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
transcription factor perturbation
0.91
disease perturbation
0.79
histone modification site profile
0.78
transcription factor
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.32   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.32   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
36
lymphocyte count
1
1
1
36
lymphocyte percentage of leukocytes
2
2
2
30.8
neutrophil percentage of leukocytes
2
1
2
2.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
36
lymphocyte count
1
36
lymphocyte percentage of leukocytes
2
30.8
neutrophil percentage of leukocytes
2
2.3
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (49)
1 – 10 of 49
KCTD17
Tbio
Novelty: 0.12105733
p_int: 0.999999033
p_ni: 1.68e-7
p_wrong: 7.99e-7
Score: 0.744
Data Source: BioPlex,STRINGDB
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.999998269
p_ni: 0.000001727
p_wrong: 4e-9
Data Source: BioPlex
PDZK1P1
Tdark
p_int: 0.999995194
p_ni: 0.000004508
p_wrong: 2.98e-7
Data Source: BioPlex
RGS3
Tbio
Novelty: 0.01749541
p_int: 0.9998864
p_ni: 0.000113513
p_wrong: 8.7e-8
Data Source: BioPlex
GNG2
Tbio
Novelty: 0.04807242
p_int: 0.999863403
p_ni: 0.000136533
p_wrong: 6.4e-8
Data Source: BioPlex
REPIN1
Tbio
Family: TF
Novelty: 0.01152362
p_int: 0.998388442
p_ni: 0.001611205
p_wrong: 3.53e-7
Score: 0.537
Data Source: BioPlex,STRINGDB
TMEM255A
Tdark
Novelty: 1.03700118
p_int: 0.998127649
p_ni: 0.001857378
p_wrong: 0.000014973
Score: 0.234
Data Source: BioPlex,STRINGDB
TNFSF14
Tbio
Novelty: 0.01370893
p_int: 0.99434193
p_ni: 0.00157746
p_wrong: 0.004080609
Data Source: BioPlex
GLRA3
Tchem
Family: IC
Novelty: 0.0209653
p_int: 0.982674931
p_ni: 0.017309382
p_wrong: 0.000015687
Score: 0.39
Data Source: BioPlex,STRINGDB
ARRDC1
Tbio
Novelty: 0.10481621
p_int: 0.980631309
p_ni: 0.000793548
p_wrong: 0.018575142
Score: 0.607
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  2.32

PubMed score by year
PubTator Score  2.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer