You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
MELK
Maternal embryonic leucine zipper kinase

Protein Summary
Description
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298048
  • ENSP00000298048
  • ENSG00000165304
  • ENST00000536329
  • ENSP00000443550
  • ENST00000536860
  • ENSP00000439792
  • ENST00000536987
  • ENSP00000439184
  • ENST00000541717
  • ENSP00000437804
  • ENST00000543751
  • ENSP00000441596
  • ENST00000545008
  • ENSP00000445452

Symbol
  • KIAA0175
  • HPK38
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
molecular function
0.97
interacting protein
0.96
protein domain
0.92
histone modification site profile
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.38   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 436   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.38   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 436   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 658
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1