Protein Summary
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]
- ENST00000257934
- ENSP00000257934
- ENSG00000135476
- ENST00000552462
- ENSP00000449831
- ESP1
- KIAA0165
- ESP1
- SEPA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
co-expressed gene | 0.95 | ||
histone modification site profile | 0.86 | ||
virus perturbation | 0.85 | ||
biological process | 0.81 | ||
kinase | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 295.34 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 634 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 295.34 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 634 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (393)
PTTG1
Novelty: 0.00304349
p_int: 0.999997844
p_ni: 0.000002125
p_wrong: 3.2e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ARMC5
Novelty: 0.02895521
p_int: 0.974276302
p_ni: 0.025723697
p_wrong: 1e-9
Data Source: BioPlex
GATD1
Family: Enzyme
Novelty: 0.40291197
p_int: 0.918061107
p_ni: 0.081938893
Data Source: BioPlex
IARS2
Family: Enzyme
Novelty: 0.00854621
p_int: 0.899207793
p_ni: 0.100792206
p_wrong: 1e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
TULP2
Family: TF
Novelty: 0.20144336
p_int: 0.873699087
p_ni: 0.126300831
p_wrong: 8.2e-8
Data Source: BioPlex
DNAJC7
Novelty: 0.02133191
p_int: 0.869100731
p_ni: 0.13089923
p_wrong: 3.9e-8
Data Source: BioPlex
CAPN2
Novelty: 0.00431673
p_int: 0.86083198
p_ni: 0.139167999
p_wrong: 2e-8
Data Source: BioPlex
CHIC1
Novelty: 0.06718561
p_int: 0.856661382
p_ni: 0.143338613
p_wrong: 4e-9
Data Source: BioPlex
CDC16
Novelty: 0.00916715
p_int: 0.843481676
p_ni: 0.1565183
p_wrong: 2.4e-8
Score: 0.992
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (12)
Reactome (6)
KEGG (3)
PathwayCommons (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | M Phase | ||||
Reactome | Mitotic Anaphase | ||||
Reactome | Mitotic Metaphase and Anaphase | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
M Phase | ||||
Mitotic Anaphase | ||||
Mitotic Metaphase and Anaphase | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (3)
Components (5)
Processes (9)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 2 | 2 | 2 | 91.9 | |||||
reticulocyte count | 3 | 3 | 3 | 86 | |||||
bone density | 4 | 3 | 5 | 85.7 | |||||
red blood cell density measurement | 1 | 1 | 1 | 82.8 | |||||
alkaline phosphatase measurement | 2 | 1 | 1 | 8.8 | 82.8 | ||||
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean corpuscular volume | 2 | 91.9 | |||||
reticulocyte count | 3 | 86 | |||||
bone density | 5 | 85.7 | |||||
red blood cell density measurement | 1 | 82.8 | |||||
alkaline phosphatase measurement | 1 | 8.8 | 82.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | extra spindle pole bodies like 1, separase | VGNC:5369 | 451937 | |||||
Macaque | extra spindle pole bodies like 1, separase | 702136 | ||||||
Mouse | MGI:2146156 | 105988 | ||||||
Rat | RGD:1306266 | 315330 | ||||||
Dog | extra spindle pole bodies like 1, separase | VGNC:40475 | 607879 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | extra spindle pole bodies like 1, separase | |||||
Macaque | extra spindle pole bodies like 1, separase | |||||
Mouse | ||||||
Rat | ||||||
Dog | extra spindle pole bodies like 1, separase | |||||
Publication Statistics
PubMed Score 295.34
PubMed score by year
PubTator Score 160.48
PubTator score by year
Related Publications
Text Mined References (43)
GeneRif Annotations (32)
Items per page:
0 of 0
PMID | Year | Title |
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