Tbio ESPL1 Separin

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Separin

Protein / ... / Cysteine Protease / Separin

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Separin

Protein Summary

Description

Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]

Uniprot Accession IDs

• Q14674

Gene Name

• ESPL1

Ensembl ID

• ENST00000257934
• ENSP00000257934
• ENSG00000135476
• ENST00000552462
• ENSP00000449831

Symbol

• ESP1
• KIAA0165
• ESP1
• SEPA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.95
histone modification site profile	0.86
virus perturbation	0.85
biological process	0.81
kinase	0.77

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.28   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 634   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.28   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 634   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

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1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
spine bone mineral density	EFO_0007701	1	1	1		49.3
mean platelet volume	EFO_0004584	1	1	1		43.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
spine bone mineral density	EFO_0007701	1		49.3
mean platelet volume	EFO_0004584	1		43.5

Reset Zoom  Beta Count   Odds Ratio

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	extra spindle pole bodies like 1, separase	VGNC:5369	451937
Macaque	extra spindle pole bodies like 1, separase		702136
Mouse	extra spindle pole bodies 1, separase	MGI:2146156	105988
Rat	extra spindle pole bodies like 1, separase	RGD:1306266	315330
Dog	extra spindle pole bodies like 1, separase	VGNC:40475	607879

Species	Name	OMA	EggNOG	Inparanoid
Chimp	extra spindle pole bodies like 1, separase
Macaque	extra spindle pole bodies like 1, separase
Mouse	extra spindle pole bodies 1, separase
Rat	extra spindle pole bodies like 1, separase
Dog	extra spindle pole bodies like 1, separase

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q14674-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)

Reactome (6)

KEGG (3)

PathwayCommons (1)

WikiPathways (2)

Cell Cycle (R-HSA-1640170)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	M Phase	350 targets	R-HSA-68886
Reactome	Mitotic Anaphase	183 targets	R-HSA-68882
Reactome	Mitotic Metaphase and Anaphase	184 targets	R-HSA-2555396

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
M Phase	350 targets	R-HSA-68886
Mitotic Anaphase	183 targets	R-HSA-68882
Mitotic Metaphase and Anaphase	184 targets	R-HSA-2555396

Gene Ontology Terms (17)

Functions (3)

Components (5)

Processes (9)

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Items per page:

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1 – 3 of 3

GO Term	Evidence	Assigned by
cysteine-type endopeptidase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
cysteine-type peptidase activity	Traceable Author Statement (TAS)	Reactome
catalytic activity	Non-traceable Author Statement (NAS)	UniProtKB

Protein-Protein Interactions (393)

Explore Interacting Targets

1 – 10 of 393

• See Interactions on String-DB

PTTG1

Tbio

Novelty: 0.00304349

p_int: 0.999997844

p_ni: 0.000002125

p_wrong: 3.2e-8

Score: 0.999

Data Source: BioPlex,Reactome,STRINGDB

ARMC5

Tbio

Novelty: 0.02895521

p_int: 0.974276302

p_ni: 0.025723697

p_wrong: 1e-9

Data Source: BioPlex

GATD1

Tdark

Family: Enzyme

Novelty: 0.40291197

p_int: 0.918061107

p_ni: 0.081938893

Data Source: BioPlex

IARS2

Tbio

Family: Enzyme

Novelty: 0.00854621

p_int: 0.899207793

p_ni: 0.100792206

p_wrong: 1e-9

Score: 0.163

Data Source: BioPlex,STRINGDB

DRC3

Tdark

Novelty: 0.99283468

p_int: 0.891861505

p_ni: 0.10813849

p_wrong: 4e-9

Data Source: BioPlex

TULP2

Tdark

Family: TF

Novelty: 0.20144336

p_int: 0.873699087

p_ni: 0.126300831

p_wrong: 8.2e-8

Data Source: BioPlex

DNAJC7

Tbio

Novelty: 0.02133191

p_int: 0.869100731

p_ni: 0.13089923

p_wrong: 3.9e-8

Data Source: BioPlex

CAPN2

Tchem

Novelty: 0.00431673

p_int: 0.86083198

p_ni: 0.139167999

p_wrong: 2e-8

Data Source: BioPlex

CHIC1

Tdark

Novelty: 0.06718561

p_int: 0.856661382

p_ni: 0.143338613

p_wrong: 4e-9

Data Source: BioPlex

CDC16

Tbio

Novelty: 0.00916715

p_int: 0.843481676

p_ni: 0.1565183

p_wrong: 2.4e-8

Score: 0.992

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  289.28

PubMed score by year

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PubTator Score  160.48

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Alternative splicing
Autocatalytic cleavage
Chromosome partition
Complete proteome
Cytoplasm
Direct protein sequencing
Hydrolase
Nucleus
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

mean platelet volume
spine bone mineral density

MGI Phenotype Find Similar Targets

cellular phenotype
embryo phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
integument phenotype
liver/biliary system phenotype
mortality/aging
neoplasm
reproductive system phenotype