Pharos : Target Details

Tbio

Protein Classes

Protein Summary

Description

Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]

Uniprot Accession IDs

Q14674

Gene Name

ESPL1

Ensembl ID

ENST00000257934
ENSP00000257934
ENSG00000135476
ENST00000552462
ENSP00000449831

Symbol

ESP1
KIAA0165
ESP1
SEPA

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.95

histone modification site profile	0.86

virus perturbation	0.85

biological process	0.81

kinase	0.77

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.28 (req: < 5)

View Publications

Gene RIFs: 32 (req: <= 3)

View Gene RIFs

Antibodies: 634 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.28 (req: >= 5)

Gene RIFs: 32 (req: > 3)

Antibodies: 634 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
spine bone mineral density	EFO_0007701	1	1	1	49.3

mean platelet volume	EFO_0004584	1	1	1	43.5

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
spine bone mineral density	EFO_0007701	1	49.3

mean platelet volume	EFO_0004584	1	43.5

Beta Count

Odds Ratio

Pathways (12)

Reactome (6)

KEGG (3)

PathwayCommons (1)

WikiPathways (2)

Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170

Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278

Reactome	M Phase	350 targets	R-HSA-68886

Reactome	Mitotic Anaphase	183 targets	R-HSA-68882

Reactome	Mitotic Metaphase and Anaphase	184 targets	R-HSA-2555396

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170

Cell Cycle, Mitotic	495 targets	R-HSA-69278

M Phase	350 targets	R-HSA-68886

Mitotic Anaphase	183 targets	R-HSA-68882

Mitotic Metaphase and Anaphase	184 targets	R-HSA-2555396

Gene Ontology Terms (17)

Functions (3)

Components (5)

Processes (9)

Items per page:

1 – 3 of 3

GO Term	Evidence	Assigned by
cysteine-type endopeptidase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

cysteine-type peptidase activity	Traceable Author Statement (TAS)	Reactome

catalytic activity	Non-traceable Author Statement (NAS)	UniProtKB

Protein-Protein Interactions (393)

1 – 10 of 393

See Interactions on String-DB

PTTG1

Tbio

Novelty: 0.00304349

p_int: 0.999997844

p_ni: 0.000002125

p_wrong: 3.2e-8

Score: 0.999

Data Source: BioPlex,Reactome,STRINGDB

ARMC5

Tbio

Novelty: 0.02895521

p_int: 0.974276302

p_ni: 0.025723697

p_wrong: 1e-9

Data Source: BioPlex

GATD1

Tdark

Family: Enzyme

Novelty: 0.40291197

p_int: 0.918061107

p_ni: 0.081938893

Data Source: BioPlex

IARS2

Tbio

Family: Enzyme

Novelty: 0.00854621

p_int: 0.899207793

p_ni: 0.100792206

p_wrong: 1e-9

Score: 0.163

Data Source: BioPlex,STRINGDB

DRC3

Tdark

Novelty: 0.99283468

p_int: 0.891861505

p_ni: 0.10813849

p_wrong: 4e-9

Data Source: BioPlex

TULP2

Tdark

Family: TF

Novelty: 0.20144336

p_int: 0.873699087

p_ni: 0.126300831

p_wrong: 8.2e-8

Data Source: BioPlex

DNAJC7

Tbio

Novelty: 0.02133191

p_int: 0.869100731

p_ni: 0.13089923

p_wrong: 3.9e-8

Data Source: BioPlex

CAPN2

Tchem

Novelty: 0.00431673

p_int: 0.86083198

p_ni: 0.139167999

p_wrong: 2e-8

Data Source: BioPlex

CHIC1

Tdark

Novelty: 0.06718561

p_int: 0.856661382

p_ni: 0.143338613

p_wrong: 4e-9

Data Source: BioPlex

CDC16

Tbio

Novelty: 0.00916715

p_int: 0.843481676

p_ni: 0.1565183

p_wrong: 2.4e-8

Score: 0.992

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score 289.28

PubMed score by year

PubTator Score 160.48

PubTator score by year

Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword


Alternative splicing

Autocatalytic cleavage

Chromosome partition

Complete proteome

Cytoplasm

Direct protein sequencing

Hydrolase

Nucleus

Phosphoprotein

Polymorphism

GWAS Trait

MGI Phenotype


cellular phenotype

embryo phenotype

endocrine/exocrine gland phenotype

hematopoietic system phenotype

integument phenotype

liver/biliary system phenotype

mortality/aging

neoplasm

reproductive system phenotype