You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ESPL1
Separin

Protein Summary
Description
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257934
  • ENSP00000257934
  • ENSG00000135476
  • ENST00000552462
  • ENSP00000449831

Symbol
  • ESP1
  • KIAA0165
  • ESP1
  • SEPA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.95
histone modification site profile
0.86
virus perturbation
0.85
biological process
0.81
kinase
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.28   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 634   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.28   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 634   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
spine bone mineral density
1
1
1
49.3
mean platelet volume
1
1
1
43.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
spine bone mineral density
1
49.3
mean platelet volume
1
43.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
extra spindle pole bodies like 1, separase
VGNC:5369
451937
Macaque
extra spindle pole bodies like 1, separase
702136
Mouse
MGI:2146156
105988
Rat
RGD:1306266
315330
Dog
extra spindle pole bodies like 1, separase
VGNC:40475
607879
Species
Name
OMA
EggNOG
Inparanoid
Chimp
extra spindle pole bodies like 1, separase
Macaque
extra spindle pole bodies like 1, separase
Mouse
Rat
Dog
extra spindle pole bodies like 1, separase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14674-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
M Phase
Reactome
Mitotic Anaphase
Reactome
Mitotic Metaphase and Anaphase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
M Phase
Mitotic Anaphase
Mitotic Metaphase and Anaphase
Protein-Protein Interactions (393)
1 – 10 of 393
PTTG1
Tbio
Novelty: 0.00304349
p_int: 0.999997844
p_ni: 0.000002125
p_wrong: 3.2e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ARMC5
Tbio
Novelty: 0.02895521
p_int: 0.974276302
p_ni: 0.025723697
p_wrong: 1e-9
Data Source: BioPlex
GATD1
Tdark
Family: Enzyme
Novelty: 0.40291197
p_int: 0.918061107
p_ni: 0.081938893
Data Source: BioPlex
IARS2
Tbio
Family: Enzyme
Novelty: 0.00854621
p_int: 0.899207793
p_ni: 0.100792206
p_wrong: 1e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
DRC3
Tdark
Novelty: 0.99283468
p_int: 0.891861505
p_ni: 0.10813849
p_wrong: 4e-9
Data Source: BioPlex
TULP2
Tdark
Family: TF
Novelty: 0.20144336
p_int: 0.873699087
p_ni: 0.126300831
p_wrong: 8.2e-8
Data Source: BioPlex
DNAJC7
Tbio
Novelty: 0.02133191
p_int: 0.869100731
p_ni: 0.13089923
p_wrong: 3.9e-8
Data Source: BioPlex
CAPN2
Tchem
Novelty: 0.00431673
p_int: 0.86083198
p_ni: 0.139167999
p_wrong: 2e-8
Data Source: BioPlex
CHIC1
Tdark
Novelty: 0.06718561
p_int: 0.856661382
p_ni: 0.143338613
p_wrong: 4e-9
Data Source: BioPlex
CDC16
Tbio
Novelty: 0.00916715
p_int: 0.843481676
p_ni: 0.1565183
p_wrong: 2.4e-8
Score: 0.992
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  289.28

PubMed score by year
PubTator Score  160.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: