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Tbio
PUM1
Pumilio homolog 1

Protein Summary
Description
Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:21572425, PubMed:18328718, PubMed:21653694, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257075
  • ENSP00000257075
  • ENSG00000134644
  • ENST00000373742
  • ENSP00000362847
  • ENST00000426105
  • ENSP00000391723
  • ENST00000440538
  • ENSP00000401777

Symbol
  • KIAA0099
  • PUMH1
  • PUMH
  • HSPUM
  • PUMH1
  • PUML1
  • SCA47
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.95
protein complex
0.95
virus perturbation
0.92
transcription factor binding site profile
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.11   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.11   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (161)
RBFOX2
Tbio
Novelty:  0.00856339
p_int:  0.999646638
p_ni:  0.000353362
Score:  0.552
Data Source:  BioPlex,STRINGDB
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.998760676
p_ni:  0.001239324
Score:  0.419
Data Source:  BioPlex,STRINGDB
TRIM11
Tbio
Family:  Enzyme
Novelty:  0.02243955
p_int:  0.997077066
p_ni:  0.002922934
Score:  0.288
Data Source:  BioPlex,STRINGDB
CELF5
Tbio
Novelty:  0.04733002
p_int:  0.97223836
p_ni:  0.02776164
Score:  0.769
Data Source:  BioPlex,STRINGDB
LITAF
Tbio
Family:  TF
Novelty:  0.0097203
p_int:  0.907668458
p_ni:  0.092331542
Score:  0.175
Data Source:  BioPlex,STRINGDB
RBM47
Tbio
Novelty:  0.04787234
p_int:  0.889398628
p_ni:  0.110601373
Data Source:  BioPlex
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.888801484
p_ni:  0.111198516
Score:  0.225
Data Source:  BioPlex,STRINGDB
CLASRP
Tbio
Novelty:  0.00582947
p_int:  0.871453473
p_ni:  0.128546527
Score:  0.174
Data Source:  BioPlex,STRINGDB
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.861933496
p_ni:  0.138066504
Data Source:  BioPlex
PICALM
Tbio
Novelty:  0.00800832
Score:  0.924
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Golgi Associated Vesicle Biogenesis (R-HSA-432722)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Reactome
trans-Golgi Network Vesicle Budding
Name
Explore in Pharos
Explore in Source
Golgi Associated Vesicle Biogenesis
Membrane Trafficking
Vesicle-mediated transport
trans-Golgi Network Vesicle Budding
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
2
2
77.7
hip circumference
1
2
2
77.1
hemoglobin measurement
2
2
2
64.4
hematocrit
2
2
2
59.6
sex hormone-binding globulin measurement
2
1
2
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
77.7
hip circumference
2
77.1
hemoglobin measurement
2
64.4
hematocrit
2
59.6
sex hormone-binding globulin measurement
2
56.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pumilio RNA binding family member 1
VGNC:6968
469256
Macaque
pumilio RNA binding family member 1
704848
Mouse
MGI:1931749
80912
Rat
RGD:1307190
362609
Dog
pumilio RNA binding family member 1
VGNC:45206
478158
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pumilio RNA binding family member 1
Macaque
pumilio RNA binding family member 1
Mouse
Rat
Dog
pumilio RNA binding family member 1
Publication Statistics
PubMed Score 70.11
PubMed score by year
PubTator Score 34.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title