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Tbio
TRIP12
E3 ubiquitin-protein ligase TRIP12

Protein Summary
Description
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regula ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283943
  • ENSP00000283943
  • ENSG00000153827
  • ENST00000389044
  • ENSP00000373696
  • ENST00000389045
  • ENSP00000373697

Symbol
  • KIAA0045
  • ULF
  • ULF
  • MRD49
  • TRIP-12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
virus perturbation
1
interacting protein
0.89
disease perturbation
0.87
transcription factor binding site profile
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.63   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.63   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
1
2
68.6
body height
1
1
1
56.4
systolic blood pressure
1
1
1
46.5
waist-hip ratio
1
1
1
42.3
glomerular filtration rate
2
2
1
5.9
31.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
68.6
body height
1
56.4
systolic blood pressure
1
46.5
waist-hip ratio
1
42.3
glomerular filtration rate
1
5.9
31.1
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thyroid hormone receptor interactor 12
VGNC:2894
459994
Mouse
MGI:1309481
14897
Rat
RGD:1306607
316575
Dog
thyroid hormone receptor interactor 12
VGNC:47845
477400
Horse
thyroid hormone receptor interactor 12
VGNC:49287
100056934
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thyroid hormone receptor interactor 12
Mouse
Rat
Dog
thyroid hormone receptor interactor 12
Horse
thyroid hormone receptor interactor 12
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14669-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Protein-Protein Interactions (512)
1 – 10 of 512
CAPN1
Tchem
Novelty:  0.00252811
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.216
Data Source:  BioPlex,STRINGDB
UBE2D4
Tbio
Novelty:  0.40836104
p_int:  0.999999835
p_ni:  1.66e-7
Score:  0.965
Data Source:  BioPlex,STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
p_int:  0.999993437
p_ni:  0.000006563
Score:  0.978
Data Source:  BioPlex,STRINGDB
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.996352639
p_ni:  0.003645749
p_wrong:  0.000001612
Score:  0.908
Data Source:  BioPlex,STRINGDB
EIF3I
Tbio
Novelty:  0.04398155
p_int:  0.99424745
p_ni:  0.00575254
p_wrong:  1e-8
Score:  0.185
Data Source:  BioPlex,STRINGDB
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
p_int:  0.981862312
p_ni:  0.018137686
p_wrong:  2e-9
Data Source:  BioPlex
BCAT1
Tchem
Family:  Enzyme
Novelty:  0.00616446
p_int:  0.975142692
p_ni:  0.017851476
p_wrong:  0.007005833
Score:  0.212
Data Source:  BioPlex,STRINGDB
RP2
Tbio
Novelty:  0.12345247
p_int:  0.972349503
p_ni:  0.024086742
p_wrong:  0.003563755
Score:  0.181
Data Source:  BioPlex,STRINGDB
CYTH4
Tbio
Novelty:  0.05783135
p_int:  0.960085088
p_ni:  0.039914671
p_wrong:  2.41e-7
Data Source:  BioPlex
OPCML
Tbio
Novelty:  0.01569352
p_int:  0.957055449
p_ni:  0.029848371
p_wrong:  0.01309618
Score:  0.254
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  36.63

PubMed score by year
PubTator Score  21.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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