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Tbio
KIAA0100
Protein KIAA0100

Protein Summary
Description
May be involved in membrane trafficking. This gene was initially characterized in human as having high expression levels in breast carcinomas and breast cancer cell lines. This gene also has increased expression in prostrate cancer cells relative to normal prostrate tissues. Expression of this gene is negatively regulated by direct binding of the microRNA miR-195 to its 3' UTR. miR-195 has been shown to modulate the invasiveness of prostrate cancer cells and xenograft metastases by downgrading expression of this gene. In mouse, the protein encoded by this gene was identified as an antigen on acute monocytic leukemia cells. In human, alternative splicing results in multiple transcript variants encoding distinct isoforms; some of these isoforms are predicted to contain an RNA pol II promoter FMP27 protein domain and a Golgi-body-localization APT1 domain. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000528896
  • ENSP00000436773
  • ENSG00000007202

Symbol
  • BCOX1
  • BCOX
  • BCOX1
  • CT101
  • FMP27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor
0.84
transcription factor perturbation
0.8
disease perturbation
0.79
cell line
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.91   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.91   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
2
2
83
reticulocyte measurement
1
1
1
58.4
mean platelet volume
1
1
1
44.2
total cholesterol measurement
1
1
1
35
tonsillectomy risk measurement
1
1
0
1.1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
83
reticulocyte measurement
1
58.4
mean platelet volume
1
44.2
total cholesterol measurement
1
35
tonsillectomy risk measurement
0
1.1
24.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
KIAA0100 ortholog
709307
Mouse
MGI:1919753
72503
Rat
RGD:1307929
303280
Dog
KIAA0100
VGNC:42341
480625
Horse
KIAA0100
VGNC:19354
100072067
Species
Name
OMA
EggNOG
Inparanoid
Macaque
KIAA0100 ortholog
Mouse
Rat
Dog
KIAA0100
Horse
KIAA0100
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14667-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (48)
1 – 10 of 48
TEX28
Tdark
Novelty:  0.10581423
p_int:  0.999988428
p_ni:  0.000011572
Score:  0.161
Data Source:  BioPlex,STRINGDB
DNAJC7
Tbio
Novelty:  0.02133191
p_int:  0.999984856
p_ni:  0.000015144
Score:  0.201
Data Source:  BioPlex,STRINGDB
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.995834352
p_ni:  0.004018529
p_wrong:  0.00014712
Data Source:  BioPlex
RNF126
Tbio
Family:  Enzyme
Novelty:  0.08123801
p_int:  0.995310898
p_ni:  0.004239451
p_wrong:  0.000449651
Score:  0.27
Data Source:  BioPlex,STRINGDB
PSMC4
Tchem
Family:  Enzyme
Novelty:  0.01717597
p_int:  0.9870055
p_ni:  0.012605281
p_wrong:  0.000389219
Score:  0.193
Data Source:  BioPlex,STRINGDB
DOCK5
Tbio
Novelty:  0.03153692
p_int:  0.951367407
p_ni:  0.030725737
p_wrong:  0.017906856
Score:  0.168
Data Source:  BioPlex,STRINGDB
MOXD1
Tbio
Family:  Enzyme
Novelty:  0.00571213
Score:  0.634
Data Source:  STRINGDB
SSU72
Tbio
Family:  Enzyme
Novelty:  0.02342759
Score:  0.618
Data Source:  STRINGDB
KATNBL1
Tdark
Novelty:  1.43589506
Score:  0.606
Data Source:  STRINGDB
TRAPPC11
Tbio
Novelty:  0.05737444
Score:  0.58
Data Source:  STRINGDB
Publication Statistics
PubMed Score  10.91

PubMed score by year
PubTator Score  5.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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