Tbio LAGE3 EKC/KEOPS complex subunit LAGE3

Protein Summary

Description

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex. This gene belongs to the ESO/LAGE gene family, members of which are clustered together on chromosome Xq28, and have similar exon-intron structures. Unlike the other family members which are normally expressed only in testis and activated in a wide range of human tumors, this gene is ubiquitously expressed in somatic tissues. The latter, combined with the finding that it is highly conserved in mouse and rat, suggests that the encoded protein is functionally important. An intronless pseudogene with high sequence similarity to this gene is located on chromosome 9. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q14657
• Q5HY39
• Q8IZ78

Gene Name

• LAGE3

Ensembl ID

• ENST00000357360
• ENSP00000349923
• ENSG00000196976

Symbol

• DXS9879E
• ESO3
• ITBA2
• CVG5
• ESO3
• Pcc1
• ITBA2
• GAMOS2
• DXS9879E
• DXS9951E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.68
kinase perturbation	0.66
tissue sample	0.66
disease perturbation	0.62
cell type or tissue	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.88   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 28   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.88   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0