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Tclin
KCNJ11
ATP-sensitive inward rectifier potassium channel 11

Protein Summary
Description
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a gr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339994
  • ENSP00000345708
  • ENSG00000187486
  • ENST00000528731
  • ENSP00000434755

Symbol
  • BIR
  • HHF2
  • PHHI
  • IKATP
  • TNDM3
  • KIR6.2
  • MODY13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.92
biological term
0.8
cell type or tissue
0.74
cellular component
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1636.54   (req: < 5)
Gene RIFs: 258   (req: <= 3)
Antibodies: 419   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1636.54   (req: >= 5)
Gene RIFs: 258   (req: > 3)
Antibodies: 419   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 96
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 18