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Tclin
KCNJ11
ATP-sensitive inward rectifier potassium channel 11

Protein Summary
Description
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a gr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339994
  • ENSP00000345708
  • ENSG00000187486
  • ENST00000528731
  • ENSP00000434755

Symbol
  • BIR
  • HHF2
  • PHHI
  • IKATP
  • TNDM3
  • KIR6.2
  • MODY13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.92
biological term
0.8
cell type or tissue
0.74
cellular component
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1457.15   (req: < 5)
Gene RIFs: 258   (req: <= 3)
Antibodies: 419   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1457.15   (req: >= 5)
Gene RIFs: 258   (req: > 3)
Antibodies: 419   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 96
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 18
Approved Drugs (18)
1 – 10 of 18
glibenclamide
chemical structure image
minoxidil
chemical structure image
pinacidil
chemical structure image
tolazamide
chemical structure image
gliclazide
chemical structure image
glipizide
chemical structure image
gliquidone
chemical structure image
glisoxepide
chemical structure image
glibornuride
chemical structure image
chlorpropamide
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
13
3
2
1.1
99.4
body mass index
3
2
3
79.9
Drugs used in diabetes use measurement
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
99.4
body mass index
3
79.9
Drugs used in diabetes use measurement
1
13.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily J member 11
VGNC:11854
466450
Mouse
MGI:107501
16514
Rat
RGD:69247
83535
Dog
potassium voltage-gated channel subfamily J member 11
VGNC:42259
485401
Horse
potassium voltage-gated channel subfamily J member 11
VGNC:19285
100056520
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily J member 11
Mouse
Rat
Dog
potassium voltage-gated channel subfamily J member 11
Horse
potassium voltage-gated channel subfamily J member 11
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14654-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (320)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
ATP sensitive Potassium channels
Reactome
Cardiac conduction
Reactome
Defective ABCC8 can cause hypoglycemias and hyperglycemias
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
ATP sensitive Potassium channels
Cardiac conduction
Defective ABCC8 can cause hypoglycemias and hyperglycemias
Gene Ontology Terms (41)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (148)
1 – 10 of 148
IL17RC
Tclin
Novelty: 0.01844832
p_int: 0.999503796
p_ni: 0.000483825
p_wrong: 0.000012379
Data Source: BioPlex
CDH5
Tbio
Novelty: 0.00072649
p_int: 0.999494611
p_ni: 0.000201024
p_wrong: 0.000304365
Data Source: BioPlex
PCDHB16
Tdark
Novelty: 0.67206411
p_int: 0.999043773
p_ni: 0.000689544
p_wrong: 0.000266682
Data Source: BioPlex
TRPM8
Tclin
Family: IC
Novelty: 0.00153949
p_int: 0.99735439
p_ni: 0.001645834
p_wrong: 0.000999776
Score: 0.29
Data Source: BioPlex,STRINGDB
PCDHAC2
Tdark
Novelty: 0.28397695
p_int: 0.996819113
p_ni: 0.002260776
p_wrong: 0.000920111
Data Source: BioPlex
GDPD5
Tbio
Family: Enzyme
Novelty: 0.05871733
p_int: 0.996381633
p_ni: 0.00256512
p_wrong: 0.001053247
Score: 0.156
Data Source: BioPlex,STRINGDB
SLC17A2
Tdark
Family: Transporter
Novelty: 0.23941275
p_int: 0.9932788
p_ni: 0.00670381
p_wrong: 0.00001739
Score: 0.157
Data Source: BioPlex,STRINGDB
MINDY2
Tbio
Novelty: 0.46783751
p_int: 0.954093574
p_ni: 0.000153659
p_wrong: 0.045752768
Score: 0.217
Data Source: BioPlex,STRINGDB
ABCC8
Tclin
Family: Transporter
Novelty: 0.00085572
Score: 0.998
Data Source: Reactome,STRINGDB
ABCC9
Tclin
Family: Transporter
Novelty: 0.01490297
Score: 0.989
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1457.15

PubMed score by year
PubTator Score  778.69

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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